Related Experiment Video

Updated: Feb 7, 2026

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
09:57

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

3.6K

Prediction of Response to Treatment in Children with Epilepsy

Mohammad Ghofrani1, Mohammad Mehdi Nasehi1, Sasan Saket1

  • 1Child Neurology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Iranian Journal of Child Neurology
|July 21, 2018
PubMed

Insights

Predicting treatment response in children with epilepsy is crucial for effective management. Abnormal electroencephalogram (EEG) findings significantly influence treatment outcomes in pediatric epilepsy patients.

Area of Science:

  • Pediatric Neurology
  • Epileptology
  • Clinical Neurophysiology

Background:

  • Epilepsy affects a significant number of children globally.
  • Predicting treatment response is essential for optimizing therapeutic strategies and improving patient outcomes.
  • Understanding factors influencing treatment efficacy in pediatric epilepsy is a key clinical challenge.

Purpose of the Study:

  • To predict treatment response in children with epilepsy receiving anti-epilepsy drugs.
  • To identify factors associated with good or poor response to anti-epilepsy drug treatment in pediatric patients.

Main Methods:

  • An analytical, questionnaire-based study involving 128 children diagnosed with epilepsy.
  • Patients aged 2 months to 12 years were followed for 6 months to assess treatment response.
  • Good response was defined as seizure freedom with two anti-epilepsy drugs during the follow-up period.

Main Results:

  • Abnormal electroencephalogram (EEG) findings were observed in 78.9% of patients.
  • A significant proportion of patients (68.8%) showed a poor response to treatment.
  • History of asphyxia (Odds Ratio = 6.82), neonatal jaundice (Odds Ratio = 2.81), and abnormal EEG (Odds Ratio = 0.19) were identified as significant factors influencing treatment response.

Conclusions:

  • Abnormal EEG is a significant predictor of treatment response in children with epilepsy.
  • Factors such as asphyxia and neonatal jaundice also play a role in treatment outcomes.
  • Further research is warranted to explore these associations and refine treatment strategies.
Abstract

Keywords:
Anti-seizure drugChildrenEpilepsyPediatricResponse to treatment

More Related Videos

Predicting Treatment Response to Image-Guided Therapies Using Machine Learning: An Example for Trans-Arterial Treatment of Hepatocellular Carcinoma04:09

Predicting Treatment Response to Image-Guided Therapies Using Machine Learning: An Example for Trans-Arterial Treatment of Hepatocellular Carcinoma

Published on: October 10, 2018

8.8K
Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy10:22

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy

Published on: December 6, 2016

21.2K

Related Concept Videos

Predicting Molecular Geometry02:27

Predicting Molecular Geometry

VSEPR Theory for Determination of Electron Pair Geometries
46.0K
Prediction Intervals01:03

Prediction Intervals

The interval estimate of any variable is known as the prediction interval. It helps decide if a point estimate is dependable.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y. 
3.4K
Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
1.4K
End Point Prediction: Gran Plot01:07

End Point Prediction: Gran Plot

A Gran plot is used to predict the equivalence volume or endpoint of a potentiometric or acid-base titration without reaching the endpoint. Typically, titration data is collected as a function of the titrant's volume up to a point less than the equivalence volume and then transformed into a linear format. The straight line is extended to the x-axis, indicating the necessary titrant volume to achieve the equivalence point.
For potentiometric titration, the Gran plot is created by plotting...
1.2K
Sensitivity, Specificity, and Predicted Value01:13

Sensitivity, Specificity, and Predicted Value

In healthcare diagnostics, laboratory tests play a crucial role in identifying and diagnosing a wide range of medical conditions. However, interpreting test results is not always straightforward. An abnormal test result does not always confirm the presence of a disease, just as a normal result does not guarantee its absence. To assess the reliability of these diagnostic tools, healthcare practitioners rely on two key statistical indicators: sensitivity and specificity.
Sensitivity is the...
1.4K
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
309