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Chronic Myelogenous Leukemia Presenting with Facial Nerve Palsy in an Infant

Ali Khajeh1, Ghasem Miri Aliabad1, Afshin Fayyazi2

  • 1Department of Pediatrics, Children and Adolescent Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.

Iranian Journal of Child Neurology
|July 21, 2018
PubMed

Insights

Pediatricians should consider chronic myelogenous leukemia (CML) in infants with seventh cranial nerve palsy and bulging fontanels, as these symptoms can indicate increased intracranial pressure. Early diagnosis of CML is crucial for timely intervention.

Area of Science:

  • Pediatric Neurology
  • Hematology
  • Oncology

Background:

  • Increased intracranial pressure in infants can manifest with cranial nerve palsy and a bulging fontanel.
  • These signs often prompt consultation with a pediatric neurologist to identify the underlying cause.

Observation:

  • This case report details an infant in eastern Iran diagnosed with chronic myelogenous leukemia (CML).
  • The infant presented with seventh cranial nerve palsy and a bulging fontanel.

Findings:

  • Peripheral blood smear analysis and chromosomal analysis confirmed the diagnosis of CML in the infant.
  • The clinical presentation mimicked other causes of increased intracranial pressure.

Implications:

  • This case highlights the importance of considering hematologic malignancies, such as CML, in the differential diagnosis of infants with neurological signs of increased intracranial pressure.
  • Early recognition and diagnosis of CML in infants can lead to prompt treatment and improved outcomes.

Keywords:
CNS involvementChildhoodChronic myelogenous leukemiaCranial nerve palsy

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