Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The adrenal cortex and virilization.

T J McKenna, S K Cunningham, T Loughlin

    Clinics in Endocrinology and Metabolism
    |November 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Diagnosis, misdiagnosis and management of hyperprolactinemia.

    Expert review of endocrinology & metabolism·2019
    Same author

    The response of renal cortical adenine nucleotides to different flush-out solutions.

    Irish journal of medical science·2016
    Same author

    The effect of plasmapheresis on the concentration of certain plasma proteins: a case identified by an inaccurate LDL-cholesterol estimation.

    Annals of clinical biochemistry·2008
    Same author

    Weight changes in type 2 diabetes and the impact of gender.

    Diabetes, obesity & metabolism·2007
    Same author

    Bioactivity of macroprolactin in the Nb2 bioassay may be explained by dissociation yielding bioactive monomeric prolactin.

    Clinical endocrinology·2007
    Same author

    The occurrence of hypothyroidism following radioactive iodine treatment of toxic nodular goiter is related to the TSH level.

    Irish journal of medical science·2007
    Same journal

    Long-term complications of diabetes.

    Clinics in endocrinology and metabolism·1986
    Same journal

    Diabetic retinopathy: current concepts of evaluation and treatment.

    Clinics in endocrinology and metabolism·1986
    Same journal

    Diabetic neuropathies and pain.

    Clinics in endocrinology and metabolism·1986
    Same journal

    The diabetic foot: pathophysiology and treatment.

    Clinics in endocrinology and metabolism·1986
    Same journal

    Autonomic neuropathy: its diagnosis and prognosis.

    Clinics in endocrinology and metabolism·1986
    Same journal

    Dialysis: continuous ambulatory peritoneal dialysis and haemodialysis.

    Clinics in endocrinology and metabolism·1986
    See all related articles

    Adrenal androgen excess contributes to idiopathic hirsutism and polycystic ovary syndrome (PCOS). Dexamethasone treatment can improve outcomes, suggesting a role for adrenal androgens in these conditions.

    Area of Science:

    • Endocrinology
    • Reproductive Medicine
    • Hormone Physiology

    Background:

    • Adrenal androgen secretion control is not fully understood, but a dexamethasone-suppressible factor, besides ACTH, may be involved.
    • Idiopathic hirsutism and polycystic ovary syndrome (PCOS) often present with signs of adrenal androgen excess.

    Purpose of the Study:

    • To investigate the role of adrenal androgens in idiopathic hirsutism and PCOS.
    • To explore the relationship between androgens, oestrone, gonadotrophins, and menstrual function.

    Main Methods:

    • Assessing androgen responsiveness to metyrapone.
    • Evaluating patient response to dexamethasone treatment (0.5 mg nightly).
    • Measuring androgen, oestrone, and gonadotrophin levels in patients with hirsutism and PCOS.

    Related Experiment Videos

    Main Results:

    • Patients with idiopathic hirsutism show elevated androgens but normal oestrogen and gonadotrophins, responding to dexamethasone.
    • PCOS patients have elevated androgens and oestrone with abnormal gonadotrophins; some respond to dexamethasone.
    • Oestrone excess, potentially from androstenedione conversion in fat, is linked to abnormal gonadotrophin secretion and PCOS development, especially in obese individuals.

    Conclusions:

    • Adrenal androgen excess plays a role in idiopathic hirsutism and PCOS.
    • Elevated oestrone levels, influenced by androstenedione conversion, are critical in PCOS pathogenesis.
    • Obesity exacerbates PCOS risk in individuals with idiopathic hirsutism due to increased oestrone production.