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Nucleic Acids02:43

Nucleic Acids

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
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Nucleic acids02:43

Nucleic acids

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
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Single Pipe Systems01:24

Single Pipe Systems

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In pipe flow analysis, problems are typically categorized into three types — Type I, Type II, and Type III — based on the known parameters and the desired outcome. Each type of problem addresses specific engineering requirements using fluid properties, pipe characteristics, and operational conditions.
In a Type I problem, fluid properties (density and viscosity), pipe characteristics (including diameter, length, and surface roughness), and the flow rate or average velocity are...
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Amino acids03:42

Amino acids

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Amino acids are the monomers that comprise proteins. Each amino acid has the same fundamental structure, which consists of a central carbon atom, or the alpha (α) carbon, bonded to an amino group (NH2), a carboxyl group (COOH), and to a hydrogen atom. Every amino acid also has another atom or group of atoms bonded to the central atom known as the R group. There are 20 common amino acids present in proteins, each with a different R group. Variation in the amino acid sequence is responsible for...
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Hydrogen Bonds00:26

Hydrogen Bonds

133.9K
Hydrogen bonds are weak attractions between atoms that have formed other chemical bonds. One of these atoms is electronegative, like oxygen, and has a partial negative charge. The other is a hydrogen atom that has bonded with another electronegative atom and has a partial positive charge.
Hydrogen Bonds Control the World!
Because hydrogen has very weak electronegativity when it binds with a strongly electronegative atom, such as oxygen or nitrogen, electrons in the bond are unequally shared....
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Acid Strength and Molecular Structure03:05

Acid Strength and Molecular Structure

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Binary Acids and Bases
In the absence of any leveling effect, the acid strength of binary compounds of hydrogen with nonmetals (A) increases as the H-A bond strength decreases down a group in the periodic table. For group 17, the order of increasing acidity is HF < HCl < HBr < HI. Likewise, for group 16, the order of increasing acid strength is H2O < H2S < H2Se < H2Te. Across a row in the periodic table, the acid strength of binary hydrogen compounds increases with increasing...
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Related Experiment Video

Updated: Feb 7, 2026

Application of Genetically Encoded Fluorescent Nitric Oxide (NO&#8226;) Probes, the geNOps, for Real-time Imaging of NO&#8226; Signals in Single Cells
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Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells

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Simultaneous Imaging of Ribonucleic Acid and Hydrogen Sulfide in Living Systems with Distinct Fluorescence Signals

Yong Liu1, Jie Niu1, Weishan Wang1

  • 1Institute of Fluorescent Probes for Biological Imaging School of Materials Science and Engineering School of Chemistry and Chemical Engineering University of Jinan Shandong 250022 P. R. China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|July 21, 2018
PubMed
Summary

Researchers developed TP-MIVC, a novel probe for simultaneous RNA and hydrogen sulfide detection. This tool distinguishes tumor tissues from normal tissues in vivo, potentially aiding cancer diagnosis.

Keywords:
dual signalshydrogen sulfideorgansribonucleic acidtumors

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Bioimaging

Background:

  • Ribonucleic acid (RNA) and hydrogen sulfide (H2S) are crucial signaling molecules in biological systems.
  • Simultaneous investigation of RNA and H2S distribution and interrelation is limited by the absence of suitable molecular tools.

Purpose of the Study:

  • To develop a novel probe for concurrent detection and imaging of RNA and H2S.
  • To establish a new method for distinguishing normal and tumor tissues using fluorescence imaging.

Main Methods:

  • Development of TP-MIVC, a probe with distinct fluorescence signals for RNA and H2S.
  • Application of TP-MIVC in cancer cells, zebrafish, and living animals, including mice.
  • Utilizing two-photon imaging properties for high-resolution in vivo studies.

Main Results:

  • TP-MIVC demonstrated high stability, low background fluorescence, and high sensitivity.
  • Concurrent imaging of RNA and H2S was achieved in various biological models.
  • Tumor tissues showed significantly stronger fluorescence intensity compared to normal tissues in mice.
  • TP-MIVC successfully distinguished between normal and tumor-bearing mice via in vivo imaging.

Conclusions:

  • TP-MIVC is the first probe capable of simultaneously reporting RNA and H2S with distinct fluorescence.
  • The probe's ability to differentiate tumor tissues offers a promising avenue for cancer diagnosis.
  • This study may pave the way for fluorescence imaging-based differentiation of malignant and benign tumors.