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Water intake keeps type 2 diabetes away? Focus on copeptin
Giovanna Muscogiuri1, Luigi Barrea2, Giuseppe Annunziata2
1Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Università Federico II di Napoli, Naples, Italy. giovanna.muscogiuri@gmail.com.
Endocrine
|July 21, 2018
Summary
High vasopressin (AVP) levels are found in diabetes. Copeptin, a stable AVP marker, may link to type 2 diabetes pathogenesis and complications, warranting further clinical investigation.
Area of Science:
- Endocrinology
- Metabolic Diseases
Background:
- Elevated vasopressin (AVP) levels are observed in diabetic subjects and animal models.
- The precise mechanisms linking AVP to glucose metabolism remain largely undefined.
Purpose of the Study:
- To review existing literature on the relationship between copeptin and type 2 diabetes.
- To explore potential molecular mechanisms underlying this association.
Main Methods:
- A systematic review of 100 manuscripts from Cochrane Library, Embase, and PubMed databases was conducted.
Main Results:
- AVP influences glucose metabolism via CRH, ACTH, and cortisol regulation, and directly impacts insulin, glucagon, hepatic glycogenolysis, and gluconeogenesis.
- AVP is implicated in diabetic complications, including cardiovascular, kidney, and ocular issues.
- Copeptin, a stable AVP surrogate, offers a more practical assay for clinical use.
Conclusions:
- Promising evidence suggests copeptin's involvement in type 2 diabetes pathogenesis.
- Further research is needed to establish copeptin as a reliable clinical marker for glucose metabolism abnormalities.
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