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Updated: Feb 7, 2026

Author Spotlight: Exploring the Link Between Time Perception of Visual Stimuli and Reading Skills
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Dopamine, time perception, and future time perspective.

Jennifer M Mitchell1,2, Dawn Weinstein3, Taylor Vega4

  • 1Department of Neurology, University of California, San Francisco, 675 Nelson Rising Lane, San Francisco, CA, 94143, USA. jennifer.mitchell@ucsf.edu.

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|July 21, 2018
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Summary
This summary is machine-generated.

Tolcapone, a COMT inhibitor, improved time perception in study participants. This enhancement was linked to genetic factors and brain activity, suggesting potential for treating decision-making disorders.

Keywords:
DopamineImpulsivityTime perceptionTime perspectiveTreatment

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Psychiatry

Background:

  • Impaired time perception is a risk factor for psychiatric conditions like substance abuse.
  • Developing therapeutics for impulsivity and decision-making disorders is crucial.

Purpose of the Study:

  • To investigate if tolcapone, a COMT inhibitor, improves time perception.
  • To explore behavioral, genetic, and neurobiological predictors of this improvement.

Main Methods:

  • A randomized, double-blind, crossover study with 66 participants.
  • Participants received tolcapone (200 mg) or placebo, completing duration estimation and other behavioral tasks.
  • Resting-state fMRI and COMT (rs4680) genotyping were performed on subsets of participants.

Main Results:

  • Tolcapone significantly improved time perception across several short durations (5-60s).
  • Improvement correlated with higher stress, depression, and alcohol consumption, and was most pronounced in COMT Val158 allele carriers.
  • Tolcapone reduced functional connectivity between the right inferior frontal gyrus and right putamen, an effect inversely correlated with improved time estimation.

Conclusions:

  • Tolcapone can ameliorate compressed time perception.
  • Further research is warranted to explore COMT inhibitors for decision-making disorders and addiction.