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Visualization of Endoplasmic Reticulum Subdomains in Cultured Cells
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Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications
Aitor Almanza1, Antonio Carlesso2, Chetan Chintha1
1Apoptosis Research Centre, National University of Ireland, Galway, Ireland.
The FEBS Journal
|July 21, 2018
Summary
The endoplasmic reticulum (ER) maintains cell balance through the unfolded protein response (UPR). This review details ER and UPR signaling, crucial for cell homeostasis and disease, with therapeutic potential.
Area of Science:
- Cell Biology
- Molecular Biology
- Biochemistry
Background:
- The endoplasmic reticulum (ER) is vital for protein folding and homeostasis.
- The unfolded protein response (UPR) is a critical signaling pathway for ER function.
- ER stress and UPR dysregulation are linked to various diseases.
Purpose of the Study:
- To provide a UPR signaling-centric review of ER functions.
- To synthesize current knowledge on ER signaling, proteostasis, and the UPR.
- To explore therapeutic applications of ER and UPR biology.
Main Methods:
- Literature review and synthesis.
- Analysis of UPR signaling pathways.
- Exploration of ER's role in cellular homeostasis and disease.
Main Results:
- The UPR aims to restore ER homeostasis but can trigger cell death if overwhelmed.
- ER signaling impacts other organelles and cellular behavior.
- The UPR is a dynamic response to cellular stress.
Conclusions:
- Understanding ER and UPR biology is crucial for maintaining cellular health.
- Targeting ER signaling pathways offers potential therapeutic strategies.
- This review integrates existing literature for future research and biomedical applications.
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