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Updated: Feb 7, 2026

High Throughput Danio Rerio Energy Expenditure Assay
Published on: January 27, 2016
A metabolic energy expenditure model with a continuous first derivative and its application to predictive simulations
Anne D Koelewijn1, Eva Dorschky2, Antonie J van den Bogert1
1a Department of Mechanical Engineering , Cleveland State University , 1960 E 24th St , Cleveland , OH , 44115 , USA.
Abstract:
Whether humans minimize metabolic energy in gait is unknown. Gradient-based optimization could be used to predict gait without using walking data but requires a twice differentiable metabolic energy model. Therefore, the metabolic energy model of Umberger et al. ( 2003 ) was adapted to be twice differentiable. Predictive simulations of a reaching task and gait were solved using this continuous model and by minimizing effort. The reaching task simulation showed that energy minimization predicts unrealistic movements when compared to effort minimization. The predictive gait simulations showed that objectives other than metabolic energy are also important in gait.
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