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Updated: Feb 7, 2026

An Objective and Reproducible Test of Olfactory Learning and Discrimination in Mice
Published on: March 22, 2018
Factors that modulate olfactory dysfunction
Kate Beecher1, James A St John2, Fatemeh Chehrehasa1
1School of Biomedical Science, Queensland University of Technology; Institute of Health and Biomedical Innovation, Queensland University of Technology; Clem Jones Centre for Neurobiology and Stem Cell Research, Griffith Institute for Drug Discovery, Griffith University, Brisbane, Queensland, Australia.
Abstract:
The olfactory system is one of a few areas in the nervous system which is capable of regeneration throughout the life. Olfactory sensory neurons reside in the nasal cavity are continuously replenished with new neurons arising from stem cells. Some factors such as aging, neurodegenerative diseases, head trauma, brain tumor extraction and infection cause olfactory dysfunction which significantly influences physical wellbeing, quality of life, mental health, nutritional status, memory processes, identifying danger and is associated with increased mortality. Therefore, finding a treatment to improve olfactory dysfunction is needed. Recent research efforts in the field have shown some very promising new approaches to treat olfactory dysfunction. This review explores the current studies that have addressed therapeutic approaches to improve olfactory neuron regeneration based on cell transplantation therapy, modulation of physiological olfactory dysfunction and drug treatments.
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