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Related Experiment Video

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Synthesis of Single-Crystalline Core-Shell Metal-Organic Frameworks

Synthesis of Single-Crystalline Core-Shell Metal-Organic Frameworks

Published on: February 10, 2023

Crystalline Cyclophane-Protein Cage Frameworks.

Ngong Kodiah Beyeh^1,2,3, Nonappa¹, Ville Liljeström¹

¹HYBER Centre of Excellence, Department of Applied Physics , Aalto University , FI-00076 Aalto , Finland.

|July 21, 2018

Summary

This summary is machine-generated.

Researchers created novel biohybrid frameworks by combining synthetic cyclophanes with protein cages. These new porous materials offer selective guest binding for applications like water remediation and catalysis.

Keywords:

crystal cyclophane electrostatic binding pillararene protein cage self-assembly

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Synthesis and Characterization of Functionalized Metal-organic Frameworks

Synthesis and Characterization of Functionalized Metal-organic Frameworks

Published on: September 5, 2014

Area of Science:

Supramolecular Chemistry
Materials Science
Biotechnology

Background:

Cyclophanes are macrocyclic hosts for molecular guests via noncovalent interactions.
Porous crystalline networks, like metal-organic frameworks, offer solid-state guest binding.
Biomolecules have not been extensively used as structural units in such frameworks.

Purpose of the Study:

To synthesize and study the self-assembly of organic cyclophanes with biological protein cages.
To develop novel biohybrid frameworks combining synthetic and biological components.
To explore the potential of these frameworks for host-guest applications.

Main Methods:

Synthesis of a library of organic cyclophanes, specifically cationic pillar[5]arenes.
Electrostatic self-assembly with biological metal-binding protein cages (ferritins).
Characterization of the resulting ordered biohybrid cocrystal structures.

Main Results:

Successful formation of biohybrid cocrystals between pillar[5]arenes and ferritin cages.
Demonstration of an open protein network structure in the cocrystals.
Bridging the gap between molecular frameworks and nanoparticle crystals.

Conclusions:

The developed cyclophane-protein cage frameworks combine synthetic host versatility with biomolecular recognition.
These biohybrid materials represent a new class of porous host-guest systems.
Potential applications include water remediation and heterogeneous catalysis.