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Published on: February 9, 2024
Characteristic properties of muscular-derived extracellular matrix and its application in rat abdominal wall defects
Zhi Yang1,2, Zhicheng Song1, Xin Nie1
1Department of General Surgery, Hernia & Abdominal Wall Surgery Center of Shanghai Jiao Tong University, Shanghai Ninth People's Hospital, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai 200011, PR China.
Aim:
To investigate the behavior of porcine-derived decellularized muscular matrix (DMM) in vitro and compare the performance of this biological mesh with that of acellular dermal matrix from pig in a full abdominal wall defect model.
Materials & Methods:
To describe the in vitro properties of the DMM scaffold with extracellular matrix histological analysis, growth factor quantification and scanning electron microscopy analysis. To compare structural and functional remodeling between acellular dermal matrix and DMM implants in a rodent full abdominal wall defect model.
Results & Conclusion:
The results demonstrated that cellular components were effectively removed in the DMM scaffold, which also maintained a 3D architecture, biochemical components and strong mechanical properties. In vivo experiments confirm that the DMM mesh could promote remodeling and reconstruction of functional skeletal muscle tissue.
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