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Updated: Feb 7, 2026

Phage-Mediated Genetic Manipulation of the Lyme Disease Spirochete Borrelia burgdorferi
Published on: September 28, 2022
Recognizing and treating Lyme disease
Scott J Saccomano1, Debra A Hrelic
1Scott J. Saccomano is an assistant professor in the College of Health and Human Services at the University of North Carolina, Wilmington, N.C. Debra A. Hrelic is the academic program coordinator for the University of North Carolina, Wilmington, in Wilmington, N.C.
Abstract:
Lyme disease is the most commonly reported vector-borne disease in the United States. After initial antibiotic treatment for patients with Lyme disease, ongoing symptoms that may persist have considerable long-term impact on healthcare costs. Posttreatment Lyme disease syndrome is characterized by a host of chronic symptoms that can leave patients physically and mentally disabled.
Insights
Posttreatment Lyme disease syndrome can cause long-term disability and significant healthcare costs, even after initial antibiotic treatment for Lyme disease. This condition impacts patients physically and mentally.
Area of Science:
- Infectious Diseases
- Public Health
- Clinical Medicine
Background:
- Lyme disease is the most frequently reported vector-borne illness in the U.S.
- Persistent symptoms after treatment can lead to substantial long-term healthcare expenses.
- Posttreatment Lyme disease syndrome (PLDS) results in chronic, disabling symptoms.
Purpose of the Study:
- To summarize the impact of Posttreatment Lyme disease syndrome.
- To highlight the chronic nature and disabling effects of PLDS.
- To underscore the economic burden associated with persistent Lyme disease symptoms.
Main Methods:
- Literature review of existing studies on Lyme disease and PLDS.
- Analysis of reported symptoms and patient outcomes.
- Examination of healthcare cost data related to chronic vector-borne diseases.
Main Results:
- PLDS is characterized by diverse chronic symptoms affecting physical and mental health.
- Patients with PLDS may experience prolonged disability.
- The economic impact of managing persistent symptoms is considerable.
Conclusions:
- Posttreatment Lyme disease syndrome presents a significant challenge due to its chronic and disabling nature.
- Effective management strategies are needed to mitigate the long-term health and economic consequences of PLDS.
- Further research is warranted to understand and treat persistent symptoms following Lyme disease.
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