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A Rat Orthotopic Renal Transplantation Model for Renal Allograft Rejection
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A 2018 Reference Guide to the Banff Classification of Renal Allograft Pathology
Candice Roufosse1,2, Naomi Simmonds3, Marian Clahsen-van Groningen4
1Department of Medicine, Imperial College, London, United Kingdom.
Transplantation
|July 21, 2018
Summary
This review simplifies the Banff Classification of Kidney Allograft Pathology, offering a clear guide for pathologists. It consolidates information from all updates, including 2017, to aid diagnosis and clinical trials.
Area of Science:
- Nephrology
- Transplant Pathology
- Immunology
Background:
- The Banff Classification of Allograft Pathology is a critical international standard for reporting solid organ transplant biopsies.
- Established in 1991 for renal transplants, it has been revised biennially, leading to dispersed information and challenges in consistent application.
- The rapid evolution of knowledge necessitates a consolidated and accessible reference for accurate diagnostic work and clinical trials.
Purpose of the Study:
- To provide a comprehensive, illustrated, and simplified reference guide to the Banff Classification of Kidney Allograft Pathology.
- To consolidate all Banff Classification updates, including the 2017 revisions, into a single, easy-to-use resource.
- To serve as a desktop reference for pathologists and clinicians, detailing definitions, Banff Lesion Scores, and Diagnostic Categories.
Main Methods:
- Systematic review of all published Banff Classification updates up to and including 2017.
- Creation of an illustrated guide with clear definitions, lesion scores, and diagnostic categories.
- Development of an online companion resource by the Banff Foundation for Allograft Pathology.
Main Results:
- A consolidated and illustrated reference guide for the Banff Classification of Kidney Allograft Pathology is presented.
- The guide incorporates all revisions and updates, offering clarity for routine diagnostics and research.
- An online platform is under development for future updates and continued refinement of the classification.
Conclusions:
- This review provides an essential, simplified reference for the Banff Classification of Kidney Allograft Pathology, addressing the challenge of dispersed information.
- The consolidated guide facilitates accurate application of the Banff Classification in clinical practice and research.
- Future refinements will be integrated into both the desktop reference and the forthcoming online resource.
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