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Lambda-cyhalothrin delays pubertal Leydig cell development in rats.

Huitao Li1, Yinghui Fang1, Chaobo Ni1

  • 1The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, 109 Xueyuan West Road, Wenzhou, Zhejiang 325027, China.

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|July 21, 2018
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Summary
This summary is machine-generated.

Lambda-cyhalothrin (LCT) exposure negatively impacts male rat reproductive health by affecting Leydig cell function and hormone levels. This insecticide disrupts testosterone production and Leydig cell gene expression, highlighting potential risks to male fertility.

Keywords:
DevelopmentLambda-cyhalothrinLeydig cellsMitochondrial membrane potentialRat

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Area of Science:

  • Reproductive Toxicology
  • Endocrinology
  • Environmental Health

Background:

  • Lambda-cyhalothrin (LCT) is a pyrethroid insecticide with widespread use.
  • Potential adverse effects on the male reproductive system are known.
  • Specific impacts on Leydig cell development during puberty remain unclear.

Purpose of the Study:

  • To investigate the effects of LCT on Leydig cell function and development in pubertal male rats.
  • To determine the impact of LCT on key reproductive hormones and Leydig cell-specific gene/protein expression.

Main Methods:

  • Male Sprague Dawley rats (28 days old) were orally administered LCT (0, 0.25, 0.5, 1 mg/kg/day) for 30 days.
  • Serum hormone levels (testosterone, LH, FSH), Leydig cell number, and gene/protein expression were analyzed.
  • Immature Leydig cells were isolated and treated with LCT in vitro to assess androgen production, gene expression, mitochondrial membrane potential, and apoptosis.

Main Results:

  • LCT exposure reduced serum testosterone and luteinizing hormone (LH) levels, while increasing follicle-stimulating hormone (FSH) levels.
  • In vivo, LCT downregulated Star and Hsd3b1 mRNA and protein expression.
  • In vitro, LCT inhibited androgen production, downregulated genes (Scarb1, Hsd3b1, Hsd11b1, Cyp11a1), and decreased mitochondrial membrane potential in Leydig cells.

Conclusions:

  • Lambda-cyhalothrin exposure adversely affects Leydig cell function during male rat puberty.
  • LCT disrupts hormone regulation and impairs Leydig cell steroidogenesis and mitochondrial function.
  • These findings suggest LCT poses a risk to male reproductive health.