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Hypothesis: why do so many lymphocytes respond to major histocompatibility antigens?

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High determinant density may explain the phenomenon of alloreactivity.

Thymic education.

Use of transgenic cell lines in mechanistic studies of drug metabolism.

Spontaneous mutation in the Cd79b gene leads to a block in B-lymphocyte development at the C' (early pre-B) stage.

T-cell control of IL-12p75 production.

The Nrarp gene encodes an ankyrin-repeat protein that is transcriptionally regulated by the notch signaling pathway.

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Astragalus polysaccharides ameliorate ulcerative colitis by targeting the HMGB1/TLR4 signaling axis to inhibit neutrophil extracellular trap formation.

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