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Related Experiment Video

Updated: Feb 7, 2026

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Dehydroepiandrosterone and Addiction.

Gal Yadid1, Hadas Ahdoot-Levi2, Tzofnat Bareli2

  • 1The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel; The Leslie and Susan Gonda (Goldschmied) Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat Gan, Israel.

Vitamins and Hormones
|July 22, 2018
PubMed
Summary

Drug addiction is a complex brain disease, not a lack of self-control. Dehydroepiandrosterone (DHEA) shows therapeutic effects, potentially aiding addiction treatment and rehabilitation.

Keywords:
AddictionCocaineCravingDehydroepiandrosteroneDrug self-administrationNeurogenesisNeurosteroidsRehabilitationRelapseReward-related memories

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Area of Science:

  • Neuroscience
  • Addiction Research
  • Pharmacology

Background:

  • Drug addiction imposes significant social and economic burdens.
  • Historically, addiction was viewed as a failure of willpower, but is now recognized as a complex brain disease.
  • Current treatments for drug addiction lack groundbreaking efficacy.

Purpose of the Study:

  • To investigate the therapeutic potential of Dehydroepiandrosterone (DHEA) in managing drug craving and relapse.
  • To explore DHEA's effects on brain circuits implicated in addiction.
  • To assess DHEA's impact on behavioral performance in animal models and human addicts.

Main Methods:

  • Review of research on DHEA's effects on addiction-related brain circuits.
  • Analysis of studies involving animal models of addiction.
  • Evaluation of clinical data from individuals undergoing DHEA treatment for addiction.

Main Results:

  • DHEA demonstrates significant therapeutic effects on brain circuits controlling addiction.
  • DHEA influences behavioral performance in both animal models and human addicts.
  • An integrative program with add-on DHEA treatment shows promise for rehabilitation.

Conclusions:

  • DHEA presents a potential alternative approach for intervention in drug addiction.
  • DHEA may support detoxification and rehabilitation processes.
  • An integrative DHEA treatment program could accelerate patient recovery and a return to normal life.