Traumatic atlanto-occipital dissociation: No longer a death sentence
Dina M Filiberto1, John P Sharpe1, Martin A Croce1
1Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee.
Background:
Traumatic atlanto-occipital dissociation is considered highly unstable and was once believed to be uniformly fatal. With recent advances in prehospital care, coupled with early diagnosis and stabilization, these injuries are potentially survivable. The aim of this study was to identify potentially modifiable risk factors associated with improved outcomes after a traumatic atlanto-occipital dissociation.
Methods:
Patients with traumatic atlanto-occipital dissociation over a 17-year period were identified and stratified by age, sex, injury severity, and severity of shock. Time to diagnosis, time to and method of stabilization, and mortality were compared. Multivariable logistic regression was performed to determine which factors were independent predictors of mortality.
Results:
Fifty-two patients were identified with a mean age of 44, an admission Glasgow Coma Score of 8, and an Injury Severity Score of 34; of these 52 patients, 38 (73%) underwent stabilization. Overall mortality was 33%. Of the survivors, 34 patients (97%) were discharged neurologically intact. One patient was discharged with neurologic deficits. Multivariable logistic regression identified admission Glasgow Coma Score (odds ratio 0.7; 95% confidence interval 0.552-0.877) as the only independent predictor of death after traumatic atlanto-occipital dissociation.
Conclusion:
Traumatic atlanto-occipital dissociation remains a rare injury following blunt trauma. Clinical presentation is a predictor of mortality. Prompt diagnosis is crucial in promoting rapid stabilization and improving survivability. Survival to hospital discharge portends improved functional outcome.
Related Concept Videos
Dissociative Disorders
Dissociative Fugue
A hallmark feature of dissociative disorders is the dissociative fugue...
Dissociative Amnesia
Traumatic Memory
Dissociative Identity Disorder
Autophagic Cell Death
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
Overview of Cell Death
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...


