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Current status of G-protein coupled receptors as potential targets against type 2 diabetes mellitus

Mehboob Hoque1, Safdar Ali1, Muddasarul Hoda1

  • 1Department of Biological Sciences, Aliah University, Kolkata 700 160, India.

International Journal of Biological Macromolecules
|July 22, 2018
PubMed

Insights

This review summarizes G protein-coupled receptors (GPCRs) and their therapeutic potential for diabetes. It highlights key GPCR targets and novel orphan GPCRs for glucose homeostasis regulation.

Area of Science:

  • Biochemistry and Pharmacology
  • Endocrinology
  • Molecular Biology

Background:

  • G protein-coupled receptors (GPCRs) are crucial cell surface receptors involved in signaling and transport.
  • They represent significant therapeutic targets for diseases including cancer and diabetes mellitus.
  • Ongoing research continually identifies and deorphanizes new GPCRs with varying expression patterns.

Purpose of the Study:

  • To categorize the diverse classes of GPCRs.
  • To identify major GPCR targets currently pursued for diabetes mellitus treatment.
  • To review recently discovered orphan GPCRs and their potential in managing diabetes.

Main Methods:

  • Literature review of GPCRs.
  • Analysis of pharmaceutical industry targets for diabetes.
  • Summary of orphan GPCR identification and functional studies.

Main Results:

  • GPCRs are implicated in glucose homeostasis through various regulatory mechanisms.
  • Several GPCRs are actively targeted by therapeutic agents (small molecules, peptides, nucleic acids, proteins) acting as agonists or antagonists.
  • Newly identified orphan GPCRs show promise for future diabetes therapies.

Conclusions:

  • GPCRs represent a vital class of therapeutic targets for diabetes mellitus.
  • Targeting specific GPCRs offers a promising strategy for regulating glucose homeostasis.
  • Further research into orphan GPCRs may unlock novel treatment avenues for diabetes.
Keywords:
Diabetes mellitusGPCRTherapeutic targets

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