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Targeting ubiquitin-proteasome pathway by natural, in particular polyphenols, anticancer agents: Lessons learned from

Seyed Fazel Nabavi1, Atanas G Atanasov2, Haroon Khan3

  • 1Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Cancer Letters
|July 22, 2018
PubMed

Insights

The ubiquitin-proteasome pathway (UPP) degrades proteins and is crucial in cancer. Certain polyphenols can target the UPP, offering potential as novel anti-cancer drugs.

Area of Science:

  • Molecular Biology
  • Biochemistry
  • Oncology

Background:

  • The ubiquitin-proteasome pathway (UPP) is the primary cellular mechanism for degrading damaged and regulatory proteins.
  • Dysregulation of the UPP is linked to cancer development and progression through altered protein stability.
  • Polyphenols are natural compounds with the ability to influence proteasome activity and subunit expression.

Purpose of the Study:

  • To review the key characteristics of the UPP.
  • To elucidate the UPP's role in cancer initiation and advancement.
  • To highlight polyphenols as potential therapeutic agents targeting the UPP for cancer treatment.

Main Methods:

  • Literature review of the ubiquitin-proteasome pathway.
  • Analysis of UPP involvement in cancer pathogenesis.
  • Evaluation of polyphenol interactions with the UPP.

Main Results:

  • The UPP regulates critical cellular processes and its components are frequently altered in cancer.
  • Modulation of the UPP can impact the stability of proteins involved in cell cycle control and tumor suppression.
  • Bioactive polyphenols demonstrate the capacity to modulate UPP function.

Conclusions:

  • The UPP is a significant therapeutic target for anti-cancer drug development.
  • Polyphenols targeting the UPP represent a promising strategy for novel cancer therapies.
  • Understanding UPP modulation by polyphenols is key to developing new anti-cancer treatments.
Keywords:
Anti-cancer agentsCancerEnzymatic modulatorOncoproteinsPolyphenolsProteasomeUbiquitinUbiquitin-proteasome pathway

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