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Zebrafish models: do we have valid paradigms for depression?

Murilo S de Abreu1, Ashton J Friend2, Konstantin A Demin3

  • 1Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil; Postgraduate Programs in Pharmacology and Environmental Sciences, Federal University of Santa Maria (UFSM), Santa Maria, Brazil.

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Summary
This summary is machine-generated.

This study advocates for using zebrafish as a novel animal model for depression research. Zebrafish offer unique advantages for understanding depression pathogenesis, despite current challenges in distinguishing depression-like states.

Keywords:
Animal modelBiological psychiatryDepressionTranslational neuroscienceZebrafish

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Animal Models

Background:

  • Depression is a widespread psychiatric disorder with significant impact.
  • Rodent models are primary tools for studying depression pathogenesis.
  • Limitations exist in current animal models for depression.

Purpose of the Study:

  • To highlight the need for innovative approaches in depression research.
  • To advocate for the use of novel model organisms, specifically zebrafish (Danio rerio).
  • To explore the potential and challenges of zebrafish in cross-species depression modeling.

Main Methods:

  • Review of recent findings in zebrafish depression research.
  • Examination of conceptual and methodological challenges.
  • Analysis of zebrafish homology to humans and rodents.

Main Results:

  • Zebrafish are increasingly valuable in translational neuroscience.
  • Recent studies show promise but face challenges in defining depression-like states.
  • Distinguishing depression from motor, social, or anxiety deficits in zebrafish is complex.

Conclusions:

  • Zebrafish present a promising novel model organism for depression research.
  • Further research is needed to overcome methodological hurdles in zebrafish depression modeling.
  • Wider adoption of zebrafish can advance cross-species depression modeling and understanding.