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Antibiotic release from F-doped nanotubular oxide layer on TI6AL4V alloy to decrease bacterial viability.

John-Jairo Aguilera-Correa1, Antonio L Doadrio2, Ana Conde3

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This study shows that F-doped nanotubular oxide layers loaded with gentamicin and vancomycin exhibit sustained antibiotic release and potent bactericidal effects against key bacterial species, offering promising antibacterial surface properties.

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Area of Science:

  • Biomaterials Science
  • Materials Chemistry
  • Infectious Disease Research

Background:

  • The development of advanced materials for orthopedic implants is crucial for preventing infections.
  • Ti-6Al-4V alloy is widely used in implants, but susceptible to bacterial colonization.
  • Nanostructured surfaces offer potential for enhanced drug delivery and antimicrobial activity.

Purpose of the Study:

  • To evaluate the release kinetics and bactericidal efficacy of gentamicin and vancomycin loaded into F-doped nanotubular anodic oxide layers on Ti-6Al-4V.
  • To assess the antibacterial activity of these functionalized surfaces against clinically relevant bacterial species.
  • To determine the potential of these surfaces for developing antibacterial, biocompatible implant materials.

Main Methods:

  • Fabrication of F-doped nanotubular oxide layers on Ti-6Al-4V.
  • Loading of gentamicin (Gm) and vancomycin (Vm), individually and in combination (Gm+Vm), into the nanotubular structures.
  • Quantification of antibiotic release using RP-HPLC and biological assays.
  • Evaluation of bactericidal activity via a bacterial adherence assay using Staphylococcus aureus, Staphylococcus epidermidis, and Pseudomonas aeruginosa.

Main Results:

  • Sustained release of gentamicin and vancomycin observed up to 120 and 180 minutes, respectively.
  • Antibiotic biological activity was maintained over time despite decreasing concentrations.
  • Significantly reduced bacterial adherence and viability on antibiotic-loaded surfaces compared to controls (P < 0.01).
  • Combined Gm+Vm loading showed enhanced efficacy against specific strains, with notable differences compared to individual antibiotics (P < 0.05).

Conclusions:

  • The F-doped nanotubular oxide layer on Ti-6Al-4V effectively loads and releases gentamicin and vancomycin.
  • This functionalized surface exhibits significant broad-spectrum bactericidal properties.
  • The developed material holds promise for creating antibacterial, biocompatible surfaces that promote tissue integration for medical implants.