Related Experiment Video
Updated: Feb 7, 2026
12:18
A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
Published on: January 11, 2020
8.1K
Heart Failure and Cognitive Impairment in the Atherosclerosis Risk in Communities (ARIC) Study
Lucy S Witt1, Jason Rotter2, Sally C Stearns3
1Department of Hospital Medicine, Atlanta Veterans Affairs Medical Center, Decatur, GA, USA. lucyswitt@gmail.com.
Journal of General Internal Medicine
|July 22, 2018
Summary
Heart failure (HF) is linked to cognitive impairment and faster decline. This study found HF patients had higher rates of dementia and mild cognitive impairment (MCI).
Area of Science:
- Neurology and Cardiology
- Cognitive Science
- Epidemiology
Background:
- Heart failure (HF) is increasingly recognized as a potential risk factor for cognitive decline.
- Understanding the relationship between HF, cognitive status, and cognitive decline in community samples is crucial for clinical risk assessment.
- Existing research suggests a link, but further investigation in diverse populations is warranted.
Purpose of the Study:
- To determine if individuals with prevalent heart failure exhibit a higher prevalence of cognitive impairment.
- To investigate whether individuals who develop heart failure experience a more accelerated rate of cognitive decline over time.
- To analyze the association between heart failure and cognitive status in a community-based cohort.
Main Methods:
- An observational cohort study utilizing data from the Atherosclerosis Risk in Communities (ARIC) study.
- Cross-sectional analysis employed multinomial logistic regression to assess prevalent HF and cognitive status.
- Longitudinal analysis examined the association between incident HF and cognitive change over a 15-year period, controlling for socio-demographic and vascular factors.
Main Results:
- Participants with heart failure showed a significantly higher prevalence of dementia (RRR=1.60) and mild cognitive impairment (MCI) (RRR=1.36) compared to those without HF.
- Individuals who developed incident heart failure experienced a greater decline in cognitive function over 15 years (-0.07 SD units) than those who did not develop HF.
- These associations remained significant after adjusting for potential confounders and did not vary based on ejection fraction.
Conclusions:
- Heart failure is independently associated with neurocognitive dysfunction and decline.
- The findings highlight a significant link between HF and impaired cognitive status, independent of other comorbidities.
- Further research is necessary to elucidate the underlying pathophysiological mechanisms connecting heart failure and cognitive impairment.
More Related Videos
07:49Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach
Published on: July 21, 2023
2.0K
06:48Lexical Decision Task for Studying Written Word Recognition in Adults with and without Dementia or Mild Cognitive Impairment
Published on: June 25, 2019
9.8K
Related Concept Videos
01:29Heart Failure II: Pathophysiology
975
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
975
01:17Pathophysiology of Heart Failure
3.8K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
3.8K
01:27Heart Failure I: Introduction
924
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
924
01:22Heart Failure VI: Adjunct Therapies
368
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
368
01:22Heart Failure Drugs: Diuretics
990
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
990
01:30Heart Failure V: Medical Management
342
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
342