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Related Concept Videos

Curing of Concrete01:20

Curing of Concrete

369
The hydration of cement takes place within the water-filled capillary pores. However, environmental elements can disrupt this process by evaporating water from the concrete surfaces. Sealed concrete with a water-cement ratio below 0.5 experiences self-desiccation, leading to water loss. The water loss in concrete is mitigated by curing. This technique involves keeping the concrete saturated to maintain the necessary temperature and moisture conditions, to optimally fill the spaces in the cement...
369
Curing Methods01:26

Curing Methods

304
Concrete members with a small surface-to-volume ratio are cured by oiling and moistening the forms before casting the concrete member. These forms can be left in place for a prolonged period to prevent moisture loss, and can be wetted if made of a material suitable for wetting. If the forms are removed early, the concrete member is moistened and covered with polythene sheets to maintain moisture. For large horizontal concrete surfaces exposed to dry weather, a temporary covering is suspended...
304
Accelerated Curing of Concrete01:25

Accelerated Curing of Concrete

484
Accelerating concrete curing is achieved by applying heat and additional moisture. This process accelerates the hydration of the cement, resulting in an earlier strength gain in the concrete. Steam curing is a method wherein the concrete products are either transported through a chamber on a conveyor belt or encased in plastic, allowing steam at atmospheric pressure to circulate freely around them. This process begins with a phase of moist curing that typically lasts between 3 to 5 hours, after...
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Nursing Interventions I: Taxonomy of Nursing Interventions01:03

Nursing Interventions I: Taxonomy of Nursing Interventions

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Nursing interventions are chosen as part of the planning process to achieve patient outcomes. Once nursing diagnoses are determined, the goals and outcomes are specified, then the nursing interventions are selected and individualized according to the patient's situation.
A nursing intervention is a treatment or action based on scientific concepts and knowledge from the nursing, behavioral, and physical sciences. Identifying and prioritizing nursing interventions based on the desired outcome...
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Nursing Interventions II: Selecting and Classifying the Nursing Interventions01:29

Nursing Interventions II: Selecting and Classifying the Nursing Interventions

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Creating and executing a nursing diagnosis helps nurses plan care and guide patient, family, and community interventions. They are developed based on a patient's physical evaluation and support measuring the outcomes. It is not recommended to select random interventions throughout the planning process. Instead, consider the following six essential factors when choosing interventions:
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Community Based Intervention01:30

Community Based Intervention

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Community-based interventions in mental health represent a paradigm shift from institution-centered care to treatments embedded within the fabric of local communities. By prioritizing inclusion and leveraging existing societal structures, this approach fosters a supportive environment conducive to addressing mental health challenges while promoting individual dignity and agency.
Foundations of Community Mental Health Programs
Central to the success of community-based interventions is the...
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Related Experiment Video

Updated: Feb 7, 2026

Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays
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Clinical Interventions in HIV Cure Research.

Thomas Aagaard Rasmussen1, Ole S Søgaard2

  • 1Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark. thomrasm@rm.dk.

Advances in Experimental Medicine and Biology
|July 22, 2018
PubMed
Summary

Researchers are exploring new HIV cure strategies by targeting latent HIV reservoirs. While latency-reversing agents show promise in impacting HIV latency, they haven't yet reduced infected cells or prevented viral rebound during treatment interruptions.

Keywords:
Clinical trialsHIV cureHistone deacetylase inhibitorsImmunotherapyLatency-reversing agents

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Area of Science:

  • Immunology
  • Virology
  • Infectious Diseases

Background:

  • Antiretroviral therapy (ART) suppresses HIV but does not eliminate latent reservoirs in long-lived cells.
  • Latent HIV infection is the primary obstacle to achieving a cure or sustained ART-free remission.
  • Understanding HIV persistence is crucial for developing effective cure strategies.

Purpose of the Study:

  • To review clinical interventions aimed at curing HIV by targeting latent reservoirs.
  • To discuss the efficacy and limitations of current and emerging HIV cure strategies.
  • To explore the role of latency-reversing agents and immunotherapies in HIV cure research.

Main Methods:

  • Review of small-scale experimental clinical trials for HIV cure.
  • Analysis of studies involving ART intensification, genome editing, and early ART initiation.
  • Evaluation of latency-reversing agents (LRAs) and various immunotherapies.

Main Results:

  • Clinical trials have established the safety of interventions targeting HIV latency.
  • LRAs can impact the state of HIV latency in patients on suppressive ART.
  • LRAs alone have not yet reduced the frequency of latently infected cells or prevented viral rebound during analytical treatment interruptions.

Conclusions:

  • Targeting latent HIV reservoirs is essential for an HIV cure.
  • Combination therapies, including immunotherapies and latency reversal, are a promising future direction.
  • Further research is needed to develop strategies for complete HIV eradication.