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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

6.6K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.6K
Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

6.6K
Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
6.6K
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

2.5K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.5K
Yeast Signaling01:28

Yeast Signaling

17.3K
Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
17.3K
Protein Complex Assembly02:41

Protein Complex Assembly

16.8K
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
16.8K
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

2.9K
Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
2.9K

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Related Experiment Video

Updated: Feb 7, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

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The Notch Interactome: Complexity in Signaling Circuitry.

Diana M Ho1, K G Guruharsha2, Spyros Artavanis-Tsakonas3,4

  • 1Department of Cell Biology, Harvard Medical School, Boston, MA, USA.

Advances in Experimental Medicine and Biology
|July 22, 2018
PubMed
Summary

The Notch pathway regulates cell fates and homeostasis, but its misregulation causes disorders like cancer. This review examines the complex Notch interactome, integrating genetic and proteomic data for better understanding.

Keywords:
Genetic modifiersGenome-wide screensNotch signal integrationProtein-protein interactionsSignaling interactome

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Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
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Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis

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Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
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Last Updated: Feb 7, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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Published on: February 28, 2017

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Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
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Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis

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Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
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Area of Science:

  • Cellular biology
  • Developmental biology
  • Molecular biology

Background:

  • The Notch pathway is crucial for cell fate determination, proliferation, differentiation, and apoptosis in metazoans.
  • Dysregulation of Notch signaling is implicated in various diseases, notably cancer.
  • Understanding Notch's pleiotropic effects requires deciphering its complex interactions.

Purpose of the Study:

  • To review the current landscape of genetic and proteomic data concerning the Notch interactome.
  • To highlight the challenges in interpreting and analyzing the vast amount of data on Notch pathway interactions.
  • To provide a comprehensive overview of the molecular network governing Notch signaling outcomes.

Main Methods:

  • Review of large-scale genetic studies.
  • Analysis of proteomic data on Notch pathway interactors.
  • Integration of network analysis approaches.

Main Results:

  • The Notch pathway engages in extensive, context-dependent interactions with numerous genes and pathways.
  • A complex regulatory network underlies Notch's diverse biological outcomes.
  • Significant challenges exist in managing and interpreting the growing volume of Notch interactor data.

Conclusions:

  • The Notch interactome is vast and intricate, necessitating advanced analytical strategies.
  • Further research integrating genetic and proteomic data is vital for a complete understanding of Notch signaling.
  • Deciphering the Notch network is key to understanding its role in development and disease.