Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Complex Assembly02:41

Protein Complex Assembly

16.8K
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
16.8K
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

2.9K
Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
2.9K
Complex Numbers01:29

Complex Numbers

320
The real number system cannot represent the square root of a negative number, which restricts solutions for certain equations, such as quadratics with negative discriminants. To address this, the complex number system was developed, introducing the imaginary unit i, where i = √(-1). This extension allows for the representation of all roots, including those involving negative radicands.A complex number is written in the form x + yi, where x and y are real numbers. Here, x represents the...
320
Formation of Complex Ions03:45

Formation of Complex Ions

26.2K
A type of Lewis acid-base chemistry involves the formation of a complex ion (or a coordination complex) comprising a central atom, typically a transition metal cation, surrounded by ions or molecules called ligands. These ligands can be neutral molecules like H2O or NH3, or ions such as CN− or OH−. Often, the ligands act as Lewis bases, donating a pair of electrons to the central atom. These types of Lewis acid-base reactions are examples of a broad subdiscipline called coordination...
26.2K
Complex Power01:14

Complex Power

925
Power engineers have introduced the concept of complex power to determine the cumulative effect of parallel loads. This idea plays a crucial role in power analysis because it encompasses all the details related to the power consumed by a specific load.
Complex power is defined as the multiplication of the voltage and the complex conjugate of the current. The magnitude of this power, known as apparent power, is measured in volt-amperes (VA). Notably, the angle of the complex power equates to the...
925
Complexation Equilibria: Factors Influencing Stability of Complexes01:09

Complexation Equilibria: Factors Influencing Stability of Complexes

857
In complexation reactions, metal cations are the electron pair acceptors, and the ligands are the electron pair donors. The stability of the metal complexes depends primarily on the complexing ability of the central metal ion and the nature of the ligands. Generally, the complexing ability of the metal ion depends on the size and charge of the ion. As the metal ion size increases, the stability of the metal complexes decreases, provided that the valency of the metal ion and the ligands remain...
857

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Small molecule-mediated activation of Notch signal transduction.

Cell death & disease·2026
Same author

NF-κB activation in astrocytes impairs wound healing after traumatic brain injury in male mice.

Nature communications·2026
Same author

Defective Notch1 signaling in endothelial cells drives pathogenesis in a mouse model of Adams-Oliver syndrome.

The Journal of clinical investigation·2025
Same author

A noncoding mutation in the NOTCH1 gene initiates oncogenic NOTCH signaling via wild-type NICD stabilization in CLL.

Blood·2025
Same author

NOTCH1 signaling is dysregulated by loss of the deubiquitinase USP28 with del(11q), uncovering USP28 inhibition as novel therapeutic target in CLL.

Leukemia·2025
Same author

A novel hybrid biosensor for miRNA detection based on peptide nucleic acids and molecularly imprinted polymers.

Bioelectrochemistry (Amsterdam, Netherlands)·2025

Related Experiment Video

Updated: Feb 7, 2026

Decellularization of the Murine Cardiopulmonary Complex
08:34

Decellularization of the Murine Cardiopulmonary Complex

Published on: May 30, 2021

3.4K

CSL-Associated Corepressor and Coactivator Complexes.

Franz Oswald1, Rhett A Kovall2

  • 1University Medical Center Ulm, Center for Internal Medicine, Department of Internal Medicine I, University of Ulm, Ulm, Germany. franz.oswald@uni-ulm.de.

Advances in Experimental Medicine and Biology
|July 22, 2018
PubMed
Summary
This summary is machine-generated.

The Notch pathway regulates cell processes, with CSL protein acting as a key switch. Understanding CSL

Keywords:
CSLCoactivator complexCorepressor complexDNA-bindingNotchRAM domainStructure analysisTranscription

More Related Videos

Measuring Composition of CD95 Death-Inducing Signaling Complex and Processing of Procaspase-8 in this Complex
07:17

Measuring Composition of CD95 Death-Inducing Signaling Complex and Processing of Procaspase-8 in this Complex

Published on: August 2, 2021

3.0K
Assembly and Characterization of Polyelectrolyte Complex Micelles
08:44

Assembly and Characterization of Polyelectrolyte Complex Micelles

Published on: March 2, 2020

11.6K

Related Experiment Videos

Last Updated: Feb 7, 2026

Decellularization of the Murine Cardiopulmonary Complex
08:34

Decellularization of the Murine Cardiopulmonary Complex

Published on: May 30, 2021

3.4K
Measuring Composition of CD95 Death-Inducing Signaling Complex and Processing of Procaspase-8 in this Complex
07:17

Measuring Composition of CD95 Death-Inducing Signaling Complex and Processing of Procaspase-8 in this Complex

Published on: August 2, 2021

3.0K
Assembly and Characterization of Polyelectrolyte Complex Micelles
08:44

Assembly and Characterization of Polyelectrolyte Complex Micelles

Published on: March 2, 2020

11.6K

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Developmental Biology

Background:

  • The Notch signaling pathway is crucial for cellular processes like differentiation and apoptosis.
  • Dysregulation of Notch signaling is implicated in diseases including cancer and developmental disorders.
  • CSL is a central transcription factor in Notch signaling, mediating interactions with corepressors and coactivators.

Purpose of the Study:

  • To review structure-function studies of CSL-associated coregulator complexes.
  • To discuss molecular insights into CSL's role in transcriptional regulation.
  • To explore the switch between repression and activation mediated by CSL.

Main Methods:

  • Review of existing structure-function studies.
  • Analysis of molecular interactions within CSL complexes.
  • Discussion of functional consequences of CSL binding partners.

Main Results:

  • CSL acts as a molecular hub, interacting with different partners to regulate gene transcription.
  • The same interaction platforms on CSL accommodate both activating and repressing binding partners.
  • Significant structural information on CSL complexes has emerged, but the activation switch remains debated.

Conclusions:

  • CSL's role as a molecular switch in Notch target gene regulation is complex and not fully understood.
  • Further research is needed to elucidate the precise mechanisms of CSL-mediated transcriptional switching.
  • Therapeutic manipulation of CSL transcription complexes remains a future possibility.