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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

6.6K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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Replicative Cell Senescence02:15

Replicative Cell Senescence

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Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.5K
Telomeres and Telomerase02:41

Telomeres and Telomerase

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In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded...
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Far-Red Fluorescent Senescence-Associated &#946;-Galactosidase Probe for Identification and Enrichment of Senescent Tumor Cells by Flow Cytometry
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Notch and Senescence.

Matthew Hoare1,2, Masashi Narita3

  • 1Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK. matthew.hoare@cruk.cam.ac.uk.

Advances in Experimental Medicine and Biology
|July 22, 2018
PubMed
Summary

Cellular senescence, a process involving cell aging, is coordinated by the Notch pathway. This pathway influences the senescence secretome and interacts with p53, offering potential for new cancer and aging therapeutics.

Keywords:
Immune surveillanceInterleukinsNOTCHRASSASPSecretomeSenescenceTGF-beta

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Area of Science:

  • Cellular and Molecular Biology
  • Developmental Biology
  • Oncology

Background:

  • Cellular senescence, once viewed solely as a tumor suppressor mechanism, is now recognized as a dynamic process throughout life.
  • Senescent cells exert significant non-autonomous effects on their microenvironment via their secretory phenotype.
  • The coordination of diverse outputs from the senescent secretome was previously unclear.

Purpose of the Study:

  • To explore the role of the Notch pathway in the development and coordination of cellular senescence.
  • To elucidate how Notch signaling influences the composition and functional effects of the senescence secretome.
  • To highlight the interplay between Notch, p53, and senescence in cancer and aging.

Main Methods:

  • Literature review and synthesis of recent findings on Notch signaling, p53, and cellular senescence.
  • Analysis of the molecular mechanisms underlying the senescence-associated secretory phenotype (SASP).
  • Discussion of the functional and physical interactions between Notch and p53 pathways.

Main Results:

  • Recent findings suggest Notch signaling is integral to senescence development.
  • Notch pathway actively coordinates the senescence secretome's composition and effects.
  • A complex interplay exists between Notch, p53, and senescence.

Conclusions:

  • The Notch pathway plays a crucial role in orchestrating the senescence secretome.
  • Understanding the Notch-p53-senescence axis is key for future therapeutic strategies.
  • Targeting this axis may offer novel treatments for cancer and age-related diseases.