Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

6.6K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.6K
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

2.5K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.5K
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

2.9K
Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
2.9K
Protein Complex Assembly02:41

Protein Complex Assembly

16.8K
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
16.8K
Complex Numbers01:29

Complex Numbers

320
The real number system cannot represent the square root of a negative number, which restricts solutions for certain equations, such as quadratics with negative discriminants. To address this, the complex number system was developed, introducing the imaginary unit i, where i = √(-1). This extension allows for the representation of all roots, including those involving negative radicands.A complex number is written in the form x + yi, where x and y are real numbers. Here, x represents the...
320
Formation of Complex Ions03:45

Formation of Complex Ions

26.2K
A type of Lewis acid-base chemistry involves the formation of a complex ion (or a coordination complex) comprising a central atom, typically a transition metal cation, surrounded by ions or molecules called ligands. These ligands can be neutral molecules like H2O or NH3, or ions such as CN− or OH−. Often, the ligands act as Lewis bases, donating a pair of electrons to the central atom. These types of Lewis acid-base reactions are examples of a broad subdiscipline called coordination...
26.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editorial: Treating solid organ diseases with innovative chimeric-antigen receptor T-cells: current indications, progress, limitations and potential strategies.

Frontiers in immunology·2024
Same author

Antibody responses in blood and saliva post COVID-19 bivalent booster do not reveal an Omicron BA.4/BA.5- specific response.

Frontiers in immunology·2024
Same author

Exopolysaccharide-Treated Dendritic Cells Effectively Ameliorate Acute Graft-versus-Host Disease.

Transplantation and cellular therapy·2023
Same author

LKB1 isoform expression modulates T cell plasticity downstream of PKCθ and IL-6.

Molecular immunology·2023
Same author

Targeting the Cbl-b-Notch1 axis as a novel immunotherapeutic strategy to boost CD8+ T-cell responses.

Frontiers in immunology·2022
Same author

Evaluation of Cellular Targeting by Fab' vs Full-Length Antibodies in Antibody-Nanoparticle Conjugates (ANCs) Using CD4 T-cells.

Bioconjugate chemistry·2022
Same journal

Peptidomics in the Spotlight: Advanced Sample Treatment Techniques and Analytical Insights.

Advances in experimental medicine and biology·2026
Same journal

Methods for the Investigation of Protein-Ligands Interactions.

Advances in experimental medicine and biology·2026
Same journal

Sample Preparation Strategies for Microbial Cell Surface Proteomics: Integrating Shaving and Shotgun Approaches.

Advances in experimental medicine and biology·2026
Same journal

Proteomic Sample Preparation for the Petroleum Industry: A Biocorrosion Case Study.

Advances in experimental medicine and biology·2026
Same journal

Proteomic and Functional Comparison of Extracellular Vesicles from Wild-Type and Lyn-Deficient Stromal Cells.

Advances in experimental medicine and biology·2026
Same journal

Proteomic Analysis of Histone Sequence Variants and Post-translationally Modified Forms.

Advances in experimental medicine and biology·2026
See all related articles

Related Experiment Video

Updated: Feb 7, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

8.4K

Notch and T Cell Function - A Complex Tale.

Jyothi Vijayaraghavan1, Barbara A Osborne2,3

  • 1Department of Veterinary & Animal Sciences, Program in Animal Biotechnology and Biomedical Sciences, University of Massachusetts, Amherst, MA, USA.

Advances in Experimental Medicine and Biology
|July 22, 2018
PubMed
Summary
This summary is machine-generated.

The Notch signaling pathway is crucial for immune cell development. This pathway guides T lymphocyte maturation and influences mature T cell functions like activation and proliferation.

Keywords:
CD4+CD8+NotchT cellTh1Th17Th2Tregs

More Related Videos

Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands
05:48

Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands

Published on: January 2, 2018

8.0K
Parameterizing V-notch Weir Equations for Flow Monitoring in a Drainage Control Structure
07:15

Parameterizing V-notch Weir Equations for Flow Monitoring in a Drainage Control Structure

Published on: April 25, 2025

1.1K

Related Experiment Videos

Last Updated: Feb 7, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

8.4K
Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands
05:48

Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands

Published on: January 2, 2018

8.0K
Parameterizing V-notch Weir Equations for Flow Monitoring in a Drainage Control Structure
07:15

Parameterizing V-notch Weir Equations for Flow Monitoring in a Drainage Control Structure

Published on: April 25, 2025

1.1K

Area of Science:

  • Immunology
  • Developmental Biology
  • Cell Biology

Background:

  • Notch signaling is a fundamental biological pathway regulating cell fate decisions across diverse species.
  • Notch family proteins are integral to various developmental processes in both invertebrates and vertebrates.
  • The immune system relies on precise cell fate choices, making Notch a relevant pathway in immunology.

Purpose of the Study:

  • To review the critical role of Notch signaling in T lymphocyte development.
  • To elucidate the function of Notch in mature T cell activation, proliferation, and differentiation.
  • To highlight Notch's significance in the vertebrate immune system.

Main Methods:

  • This is a review article, synthesizing existing research.
  • Literature search and analysis of studies on Notch signaling in T cell development and function.
  • Compilation of data from studies in various model organisms and humans.

Main Results:

  • Notch signaling is essential for directing hematopoietic precursors towards mature T lymphocyte lineages.
  • Notch plays a significant role in regulating the activation and proliferation of mature T cells.
  • The pathway influences the differentiation of T cells, impacting their functional specialization.

Conclusions:

  • Notch signaling is indispensable for proper T lymphocyte development from precursor cells.
  • Notch signaling pathways are vital for the functional regulation of mature T cells.
  • Understanding Notch's role provides insights into immune system development and function.