Related Experiment Video
Updated: Feb 7, 2026

Techniques to Induce and Quantify Cellular Senescence
Published on: May 1, 2017
The three-dimensional organization of the genome in cellular senescence and age-associated diseases
Shane A Evans1, Jeremy Horrell2, Nicola Neretti3
1Center for Computational Molecular Biology, Brown University, Providence, RI, United States.
Abstract:
Recent advances in genomics and imaging technologies have increased our ability to interrogate the 3D conformation of chromosomes and to better understand principles of organization and dynamics, as well as how their alteration can lead to disease. In this review we describe how these technologies have shed new light into the role of the 3D organization of the genome in defining cellular states in aging and age-associated diseases. We compare the genomic organization in cellular senescence and cancer, discuss the role of the lamina in maintaining the structural and functional integrity of the genome, and we highlight the recent findings on how this organization breaks down in disease states.
Related Concept Videos
Genomics
Genomic Imprinting and Inheritance
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Replicative Cell Senescence
Genome Size and the Evolution of New Genes
Transgenic Organisms
Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

