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Increased CCL18 plasma levels are associated with neurodegenerative MRI outcomes in multiple sclerosis patients

Nicole Ziliotto1, Francesco Bernardi2, Dejan Jakimovski3

  • 1Department of Life Sciences and Biotechnology, University of Ferrara, Italy; Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.

Multiple Sclerosis and Related Disorders
|July 22, 2018
PubMed
Abstract

Insights

Higher levels of chemokine ligand 18 (CCL18) in the blood are linked to increased inflammation and brain damage in multiple sclerosis (MS) patients. This finding may help identify disease severity and progression in MS.

Area of Science:

  • Neuroimmunology
  • Biomarker Discovery

Background:

  • Macrophage activation and differentiation are implicated in multiple sclerosis (MS) pathogenesis.
  • Chemokine ligands and co-stimulatory factors play a role in these processes.

Purpose of the Study:

  • To investigate associations between C-C motif Ligand 18 (CCL18), C-C motif ligand 5 (CCL5), and soluble Cluster of Differentiation 86 (sCD86) with clinical and MRI measures in MS patients.

Main Methods:

  • Evaluated plasma levels of CCL18, CCL5, and sCD86 in 138 MS patients and 42 healthy individuals.
  • Utilized standardized 3T MRI and clinical examinations for all subjects.
  • Performed multiple regression analysis with MRI outcomes as dependent variables.

Main Results:

  • Higher CCL18 plasma levels were observed in progressive MS (P-MS) compared to relapsing-remitting MS (RR-MS) and healthy individuals.
  • Disease-modifying treatments affected CCL5 and sCD86 levels.
  • Elevated CCL18 levels correlated with increased lateral ventricular and T2 lesion volumes, and decreased grey matter, thalamic, and cortical volumes.

Conclusions:

  • Higher CCL18 plasma levels are associated with more severe inflammatory and neurodegenerative brain MRI outcomes in MS.
  • CCL18 may serve as a potential biomarker for disease severity and progression in multiple sclerosis.
Keywords:
CCL18CCL5CD86MRIMultiple sclerosisNeurodegeneration

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