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Bones and the sex hormones.
Radhika R Narla1, Susan M Ott1
1Department of Medicine, University of Washington, Seattle, Washington, USA.
Kidney International
|July 23, 2018
Summary
In men undergoing dialysis, elevated sex hormone-binding globulin and total testosterone levels were linked to nonvertebral fractures. This finding complicates understanding bone health in renal osteodystrophy.
Area of Science:
- Endocrinology
- Nephrology
- Orthopedics
Background:
- Sex hormones are crucial for skeletal integrity in men, with estrogen and testosterone influencing different bone types.
- Sex hormone-binding protein is a known fracture risk factor in the general male population.
- Renal osteodystrophy presents complex challenges to bone health in patients with chronic kidney disease.
Purpose of the Study:
- To investigate the association between sex hormones, sex hormone-binding globulin, and prevalent nonvertebral fractures in men undergoing dialysis.
- To explore the role of these factors in the context of renal osteodystrophy.
Main Methods:
- Measurement of sex hormones (estrogen, testosterone) and sex hormone-binding globulin in male patients on dialysis.
- Assessment of prevalent nonvertebral fractures in the study cohort.
Main Results:
- Higher levels of sex hormone-binding globulin were associated with prevalent nonvertebral fractures.
- Elevated total testosterone levels were also found to be associated with prevalent nonvertebral fractures.
- These associations add complexity to the understanding of bone disease in dialysis patients.
Conclusions:
- Sex hormone profiles, including sex hormone-binding globulin and total testosterone, are associated with fracture risk in men with renal osteodystrophy.
- These findings highlight the intricate interplay between hormonal regulation and bone fragility in patients undergoing dialysis.
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