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STAT3 isoforms: Alternative fates in cancer?

Petra Aigner1, Valentin Just1, Dagmar Stoiber2

  • 1Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.

Cytokine
|July 23, 2018
PubMed
Summary

Signal transducer and activator of transcription (STAT) 3, a key protein in cell signaling, has dual roles in cancer. Its isoforms, STAT3α and STAT3β, exhibit distinct functions, with STAT3α often acting as an oncogene and STAT3β as a tumor suppressor.

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