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Updated: Feb 7, 2026
06:12
Imaging Dpp Release from a Drosophila Wing Disc
Published on: October 30, 2019
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CtBP represses Dpp-dependent Mad activation during Drosophila eye development
Nadia Eusebio1, Lígia Tavares1, Paulo S Pereira1
1i3S -Instituto de Investigação e Inovação em Saúde, Porto, Portugal; IBMC- Instituto de Biologia Molecular e Celular, Porto, Portugal.
Developmental Biology
|July 23, 2018
Summary
Researchers identified key genes interacting with the Dpp signaling pathway in Drosophila eye development. Downregulating Ago partially rescued punt-dependent growth and differentiation, revealing CtBP
Area of Science:
- Developmental Biology
- Molecular Biology
- Genetics
Background:
- Complex signaling networks regulate tissue growth and differentiation.
- Dpp signaling in Drosophila eye development shifts from promoting growth to inducing cell cycle arrest and differentiation.
Purpose of the Study:
- Identify regulators and targets of Dpp signaling in retinal development.
- Characterize interactors of the Type II TGFβ receptor, Punt.
Main Methods:
- In vivo eye-targeted double-RNAi screen.
- Utilized a set of 251 genes associated with eye development.
- Investigated genetic interactions and signaling pathway activation.
Main Results:
- Identified CtBP, Dad, Ago, and Brk as Punt genetic interactors.
- Downregulation of Ago or increased tissue growth partially rescued Punt-dependent phenotypes.
- Discovered CtBP inhibits Dpp-dependent Mad activation and activates JNK signaling.
Conclusions:
- Ago and CtBP are crucial regulators in Dpp signaling during Drosophila eye development.
- CtBP plays a novel role in inhibiting Mad activation and interacts with JNK signaling.
- Findings advance understanding of signaling pathway regulation in development.
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