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Recurrent wheezing in preterm infants: Prevalence and risk factors

Maria Cristina Ribeiro Dos Santos Simões1, Yuri Inoue2, Natasha Y Matsunaga3

  • 1Universidade Estadual de Campinas (Unicamp), Faculdade de Ciências Médicas (FCM), Programa de Pós-Graduação em Saúde da Criança e do Adolescente, Campinas, SP, Brazil; Universidade Estadual de Campinas (Unicamp), Faculdade de Ciências Médicas (FCM), Departamento de Pediatria, Campinas, SP, Brazil.

Jornal De Pediatria
|July 23, 2018
PubMed

Insights

Preterm infants with lower gestational age, personal history of atopy, or living with multiple siblings face higher risks of recurrent wheezing. Passive immunization against respiratory syncytial virus was associated with increased prevalence in preterm infants with lower gestational age.

Area of Science:

  • Pediatrics
  • Neonatology
  • Allergy and Immunology

Background:

  • Recurrent wheezing is a common respiratory issue in preterm infants, impacting long-term health.
  • Identifying risk factors is crucial for early intervention and management strategies.

Purpose of the Study:

  • To determine the prevalence of recurrent wheezing in preterm infants.
  • To identify risk factors associated with the progression to recurrent wheezing in this population.

Main Methods:

  • A cross-sectional study analyzed 445 preterm infants born between 2011-2012.
  • Data was collected via questionnaires during telephone interviews.
  • Univariate and multivariate analyses were performed to identify risk factors.

Main Results:

  • Overall prevalence of recurrent wheezing was 27.4%.
  • Significant risk factors included gestational age <28 weeks, personal history of food allergy or atopic dermatitis, and living with two or more siblings.
  • Preterm infants with lower gestational age who received passive immunization for respiratory syncytial virus showed a higher prevalence of recurrent wheezing.

Conclusions:

  • Lower gestational age, personal history of atopy, and living with multiple siblings are significantly associated with recurrent wheezing.
  • Passive immunization against RSV in preterm infants with lower gestational age warrants further investigation due to observed higher prevalence of recurrent wheezing.
Abstract

Keywords:
AsmaAsthmaFatores de riscoPrevalencePrevalênciaPrevention and controlPrevenção e controleRespiratory soundsRespiratory syncytial virusRisk factorsSons respiratóriosVírus sincicial respiratório

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