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CENP-E as a target for cancer therapy: Where are we now?

Amr Ahmed El-Arabey1, Salama Abdu Salama1, Adel Rashad Abd-Allah1

  • 1Pharmacology and Toxicology Department, Faculty of Pharmacy, Al-Azhar University, Nasr City, Cairo, Egypt.

Life Sciences
|July 23, 2018
PubMed

Insights

Centromere-associated Protein E (CENP-E) is crucial for accurate chromosome alignment during mitosis. Targeting CENP-E offers a promising new chemotherapy strategy for solid tumors lacking targeted therapies.

Area of Science:

  • Oncology
  • Cell Biology
  • Genetics

Background:

  • Cancer is a complex disease characterized by uncontrolled cell growth and genomic instability.
  • Mitosis is a key target for chemotherapy, with drugs like taxol and colchicine inhibiting cell division by affecting mitotic spindle plasticity.
  • Centromere-associated Protein E (CENP-E) is implicated in inaccurate chromosome alignment during mitosis.

Purpose of the Study:

  • To explore Centromere-associated Protein E (CENP-E) as a potential therapeutic target in oncology.
  • To investigate the role of CENP-E in cancer cell division and its implications for chemotherapy.
  • To highlight the challenges and future prospects of CENP-E-targeted therapies.

Main Methods:

  • Review of accumulating evidence on CENP-E's role in mitosis.
  • Analysis of CENP-E expression patterns during the cell cycle.
  • Exploration of CENP-E's druggability for cancer treatment.

Main Results:

  • CENP-E is expressed during mitosis and plays a critical role in chromosome alignment.
  • Dysregulation of CENP-E can lead to genomic instability.
  • CENP-E is not implicated in neuronal function, suggesting a specific therapeutic window.

Conclusions:

  • Centromere-associated Protein E (CENP-E) represents a promising druggable target for chemotherapy in solid tumors.
  • Targeting CENP-E may offer a novel therapeutic strategy for cancers lacking targeted treatments.
  • Further research into CENP-E inhibitors is warranted for clinical oncology applications.
Keywords:
Anti-mitoticCENP-ECancerChemotherapyInhibitorTargeted therapy

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