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The naming of enantiomers employs the Cahn–Ingold–Prelog rules that involve assigning priorities to different substituent groups at a chiral center. Each enantiomer, being a distinct molecule, is assigned a unique name by the Cahn–Ingold–Prelog (CIP) rules, also called the R–S system. The prefix R- or S- attached to the chiral centers in an enantiomer is dependent on the spatial arrangement of the four substituents on the chiral center. The R–S system essentially comprises three...
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Articles linked to this work by shared authors, journal, and citation graph.

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Validation List no. 227: valid publication of new names and new combinations effectively published outside the <i>IJSEM</i>.

International journal of systematic and evolutionary microbiology·2026
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Notification that new names of prokaryotes, new combinations and new taxonomic opinions have appeared in volume 75, part 10 of the <i>IJSEM</i>.

International journal of systematic and evolutionary microbiology·2026
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Notification of changes in taxonomic opinion previously published outside the <i>IJSEM</i>: List of Changes in Taxonomic Opinion no. 43.

International journal of systematic and evolutionary microbiology·2026
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Jean Paul Euzéby (1949-2025).

International journal of systematic and evolutionary microbiology·2025
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Notification that new names of prokaryotes, new combinations and new taxonomic opinions have appeared in volume 75, part 9 of the <i>IJSEM</i>.

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Related Experiment Video

Updated: Feb 7, 2026

Development of a Larval Zebrafish Infection Model for Clostridioides difficile
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Clostridium difficile and Clostridioides difficile: Two validly published and correct names.

Aharon Oren1, Maja Rupnik2

  • 1Department of Plant and Environmental Sciences, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem, 9190401, Israel.

Anaerobe
|July 23, 2018
PubMed
Summary
This summary is machine-generated.

The correct name for the pathogen commonly known as Clostridium difficile is currently debated. Both Clostridium difficile and Clostridioides difficile are validly published names and can be used.

Keywords:
Clostridioides difficileClostridium difficileNomenclatureProkaryotic CodeTaxonomy

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Area of Science:

  • Microbiology
  • Bacteriology
  • Taxonomy

Background:

  • The bacterium Clostridium difficile is a significant human pathogen.
  • There is ongoing confusion regarding the correct nomenclature for this organism.

Purpose of the Study:

  • To clarify the taxonomic status and correct naming of Clostridium difficile.
  • To address the confusion surrounding the pathogen's scientific name.

Main Methods:

  • Review of the Prokaryotic Code of Nomenclature.
  • Analysis of the publication status of both names.

Main Results:

  • Both "Clostridium difficile" and "Clostridioides difficile" have been validly published.
  • The Prokaryotic Code provisions allow for the use of both names.

Conclusions:

  • The nomenclature of this important pathogen remains ambiguous.
  • Both Clostridium difficile and Clostridioides difficile are currently acceptable scientific names.