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Unknown primary carcinoma in the Netherlands: decrease in incidence and survival times remain poor between 2000 and

C Schroten-Loef1, R H A Verhoeven1, I H J T de Hingh2

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European Journal of Cancer (Oxford, England : 1990)
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The incidence of unknown primary tumour (UPT) decreased in the Netherlands from 2000-2012. Survival for UPT patients remains poor, with only one-third receiving treatment and median survival measured in months.

Keywords:
Cancer registryIncidenceOncologyPopulation-basedSurvivalUnknown primary carcinoma

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Area of Science:

  • Oncology
  • Cancer Epidemiology

Background:

  • Unknown primary tumour (UPT) presents diagnostic and treatment challenges due to the unidentified origin of metastatic cancer.
  • Limited data exists on the incidence, treatment, and survival rates of UPT patients.
  • This study analyzes UPT data from the Netherlands between 2000 and 2012.

Purpose of the Study:

  • To report incidence, patient characteristics, treatment patterns, and survival rates for Unknown Primary Tumour (UPT) in the Netherlands.
  • To compare the age-standardised rate of unspecified malignancies in the Netherlands with European averages.

Main Methods:

  • Utilized data from the Netherlands Cancer Registry (NCR) for patients diagnosed with UPT between 2000 and 2012.
  • Calculated incidence rates and assessed patient demographics, treatment modalities, and survival outcomes.
  • Compared Dutch age-standardised rates for 'other and unspecified' malignancies with European data.

Main Results:

  • The incidence of UPT in the Netherlands decreased from 14 to 7.0 per 100,000 person-years between 2000 and 2012.
  • The most frequent metastatic sites were liver, lymph nodes, bone, and lung.
  • Median survival for all UPT patients was 1.7 months; treated patients had a median survival of 6.3 months, compared to 1.0 month for untreated patients.

Conclusions:

  • The incidence of UPT is declining in the Netherlands.
  • A significant proportion of UPT patients (approximately two-thirds) do not receive treatment.
  • Survival outcomes for UPT patients remain limited, emphasizing the need for improved diagnostic and therapeutic strategies.