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Treatment of arterial thrombosis in children: Methods and mechanisms

Mattia Rizzi1, Manuela Albisetti2

  • 1Hematology/Oncology Unit, Division of Pediatrics, University Hospital CHUV, Lausanne, Switzerland.

Thrombosis Research
|July 23, 2018
PubMed

Insights

Pediatric arterial thrombosis, often linked to catheters or stroke, lacks treatment guidelines. This review explores adult thrombosis mechanisms and current pediatric antithrombotic therapies.

Area of Science:

  • Pediatric thrombosis
  • Vascular medicine
  • Hematology

Background:

  • Arterial thrombosis in children is a growing concern, frequently associated with arterial catheters or ischemic stroke.
  • Current treatment strategies for pediatric arterial thrombosis are diverse and lack evidence-based guidelines.
  • Understanding thrombosis mechanisms is key to selecting effective antithrombotic agents, as suggested by adult data.

Purpose of the Study:

  • To review current insights into the pathomechanism and composition of arterial thrombosis in adults.
  • To describe the antithrombotic treatment modalities presently employed in pediatric cases.
  • To bridge the gap in evidence-based guidelines for pediatric arterial thrombosis management.

Main Methods:

  • Literature review focusing on adult arterial thrombosis pathomechanisms.
  • Compilation and analysis of existing antithrombotic treatments used in pediatric patients.
  • Synthesis of findings to inform potential guideline development.

Main Results:

  • Adult arterial thrombosis involves complex pathomechanisms and variable composition.
  • Pediatric treatments primarily utilize available anticoagulant and antiplatelet drugs.
  • Significant variability exists in current pediatric treatment approaches.

Conclusions:

  • Further research is needed to establish evidence-based guidelines for pediatric arterial thrombosis.
  • Tailoring antithrombotic therapy based on thrombosis characteristics may improve outcomes.
  • Translating adult thrombosis insights to pediatric care requires careful consideration.

Keywords:
Arterial thrombosisChildrenMethodsTreatment

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