Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bipolar Disorder01:30

Bipolar Disorder

817
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
817
Autism Spectrum Disorder01:19

Autism Spectrum Disorder

1.2K
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
1.2K
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

560
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
560
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

798
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
798
The Electromagnetic Spectrum02:37

The Electromagnetic Spectrum

65.4K
The electromagnetic spectrum consists of all the types of electromagnetic radiation arranged according to their frequency and wavelength. Each of the various colors of visible light has specific frequencies and wavelengths associated with them, and you can see that visible light makes up only a small portion of the electromagnetic spectrum. Because the technologies developed to work in various parts of the electromagnetic spectrum are different, for reasons of convenience and historical...
65.4K
Long-term Depression01:05

Long-term Depression

33.3K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[A case of bilateral chylous aqueous humor].

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology·2025
Same author

[Comparative analysis on the 2024 Japanese guidelines for management of lung nodules detected by low-dose CT lung cancer screening and the 2023 Chinese guidelines for low-dose CT lung cancer screening].

Zhonghua zhong liu za zhi [Chinese journal of oncology]·2025
Same author

[Research progress on DNA methylation as a diagnostic biomarker for malignant mesothelioma].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases·2025
Same author

[Laparoscopic modified transcystic biliary drainage for the treatment of biliary stones and diagnosis of biliary disease].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences·2025
Same author

[Tornwaldt cysts in a child: a case report].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery·2025
Same author

[Acute fatty liver of pregnancy with severe coagulopathy: a case report and review].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi·2025

Related Experiment Video

Updated: Feb 7, 2026

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

1.5K

Bipolar spectrum in major depressive disorders.

J Angst1, K R Merikangas2, L Cui2

  • 1Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland. jules.angst@uzh.ch.

European Archives of Psychiatry and Clinical Neuroscience
|July 23, 2018
PubMed
Summary

Subthreshold manic syndromes in major depressive disorder (MDD) resemble bipolar II disorder, while manic symptoms alone present intermediate features. This supports a mood disorder spectrum, impacting differential diagnosis and treatment strategies for depression.

Keywords:
Bipolar spectrumEpidemiologyHypomaniaMajor depressionMania

More Related Videos

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
08:20

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

Published on: August 11, 2015

14.7K
Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment
05:19

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Published on: July 7, 2023

3.5K

Related Experiment Videos

Last Updated: Feb 7, 2026

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

1.5K
MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
08:20

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

Published on: August 11, 2015

14.7K
Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment
05:19

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Published on: July 7, 2023

3.5K

Area of Science:

  • Psychiatry
  • Mood Disorders
  • Diagnostic Classification

Background:

  • The spectrum concept challenges categorical diagnoses in mental health.
  • Identifying manic symptoms in depression is crucial for bipolar vs. unipolar depression treatment.
  • Current diagnostic systems may oversimplify mood disorder presentations.

Purpose of the Study:

  • To investigate subthreshold manic syndromes and symptoms in Major Depressive Disorder (MDD).
  • To compare clinical correlates of these subthreshold manifestations with MDD alone and Bipolar II Disorder.
  • To assess the validity of the mood disorder spectrum concept.

Main Methods:

  • Defined two subthreshold manic manifestations: manic syndrome and manic symptoms, excluding duration criteria.
  • Compared clinical characteristics of MDD patients with and without these subthreshold manic features.
  • Utilized comparative analysis against MDD alone and Bipolar II Disorder cohorts.

Main Results:

  • MDD patients with subthreshold manic syndromes showed clinical correlates similar to Bipolar II Disorder.
  • MDD patients with only manic symptoms were intermediate between subthreshold manic syndrome and MDD alone.
  • Findings support a continuum of mood disorders, challenging strict diagnostic boundaries.

Conclusions:

  • The study confirms the spectrum concept of mania within mood disorders.
  • Subthreshold manic syndromes in MDD warrant consideration for accurate diagnosis.
  • Results suggest a need to re-evaluate diagnostic criteria for mood disorders.