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[MicroPET-CT study of the association between odor stimulation and olfactory related brain activation in rats]

X Gao1, Z F Sun1, X G Yan1

  • 1Department of Otorhinolaryngology Head and Neck Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi = Chinese Journal of Otorhinolaryngology Head and Neck Surgery
|July 23, 2018
PubMed

Insights

This study demonstrates that (18)F-fluorodeoxyglucose (FDG) PET-CT can objectively validate rat olfactory function. Different odors, like isovaleric acid (IVA), activate specific brain regions, confirming PET-CT

Area of Science:

  • Neuroscience
  • Medical Imaging
  • Animal Models

Background:

  • Olfactory function assessment in rodents typically relies on behavioral tests.
  • Objective, quantitative methods for evaluating olfactory pathways are needed.
  • Positron Emission Tomography-Computed Tomography (PET-CT) offers high sensitivity for metabolic imaging.

Purpose of the Study:

  • To assess the feasibility of using (18)F-fluorodeoxyglucose ((18)F-FDG) PET-CT to objectively validate rat olfactory function.
  • To determine if (18)F-FDG PET-CT can differentiate brain metabolic responses to distinct odor stimuli.
  • To establish (18)F-FDG PET-CT as a potential new method for examining olfactory pathways.

Main Methods:

  • Six male Sprague-Dawley rats with confirmed normal olfactory function (via buried food pellet test) were studied.
  • (18)F-FDG was administered intravenously, followed by 30-minute exposure to pure air, phenethyl alcohol (PEA), or isovaleric acid (IVA).
  • Static microPET-CT scans were performed under anesthesia, with image analysis using SPM and VBM methods.

Main Results:

  • Phenethyl alcohol (PEA) stimulation resulted in brain activation in the bed nucleus and insula.
  • Isovaleric acid (IVA) stimulation elicited significant metabolic activation across multiple olfactory-related regions, including the olfactory bulb, amygdala, and piriform cortex (P<0.005).
  • Distinct odorants induced differential metabolic activation patterns in specific brain areas.

Conclusions:

  • MicroPET-CT imaging with (18)F-FDG successfully visualized metabolic brain activation in response to olfactory stimulation in rats.
  • The observed activation patterns correlated with known olfactory processing regions.
  • (18)F-FDG PET-CT is a feasible method for objective olfactory function assessment, with isovaleric acid (IVA) showing strong responses in related brain regions.
Keywords:
Fluorodeoxyglucose F18Olfactory cortexPET-CTRats

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