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[Association between serum lipid level and depression in patients with chronic heart failure]

X H Gu1, K J Wu, F Y Ni

  • 1Graduate School of Xi'an Medical College, Xi'an 710068, China.

Zhonghua Yi Xue Za Zhi
|July 23, 2018
PubMed

Insights

In chronic heart failure (CHF) patients, higher total cholesterol levels correlate with increased depression risk, while higher high-density lipoprotein cholesterol levels are linked to reduced depression. These lipid profiles are key factors in CHF-related depression.

Area of Science:

  • Cardiology
  • Psychiatry
  • Metabolic Disorders

Background:

  • Depression is a common comorbidity in patients with chronic heart failure (CHF).
  • Serum lipid levels, including cholesterol and lipoproteins, play a role in cardiovascular health and may influence mental health outcomes.

Purpose of the Study:

  • To examine the relationship between serum lipid profiles and the prevalence and severity of depression in patients diagnosed with CHF.

Main Methods:

  • A cohort of 348 CHF patients was assessed using the Hamilton Depression Scale (HAMD).
  • Serum lipid levels (total cholesterol, LDL-C, HDL-C, triglycerides) were measured.
  • Pearson correlation and Logistic regression analyses were employed to evaluate associations and confounding factors.

Main Results:

  • A significant difference in depression prevalence was observed between patients with normal lipid levels and those with dyslipidemia (P=0.044).
  • Depression scores showed a positive linear correlation with total cholesterol (r=0.326, P<0.001) and low-density lipoprotein cholesterol (LDL-C) (r=0.354, P<0.001).
  • Logistic regression indicated that elevated total cholesterol (OR=3.523, P=0.007) and reduced high-density lipoprotein cholesterol (HDL-C) (OR=0.205, P=0.041) were independently associated with depression in CHF patients.

Conclusions:

  • Total cholesterol is identified as a risk factor that can increase the likelihood of depression in CHF patients.
  • High-density lipoprotein cholesterol demonstrates a protective effect, potentially reducing the risk of depression in this population.

Keywords:
DepressionDyslipidemiasHeart failure

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