[Laparoscopic versus open surgery for simultaneous resection of synchronous colorectal liver metastases]

Objective: To compare the short-term outcomes and long-term outcomes between open and laparoscopic approaches for simultaneous resection of primary colorectal cancer and synchronous liver metastases. Methods: Patients underwent simultaneous resection of primary colorectal cancer and synchronous liver metastases at Department of General Surgery, Huashan Hospital, Fudan University between January 2014 and October 2017 were included.The totally laparoscopic surgery patients were matched 1∶1 based on propensity score to the open surgery patients.Continuous and categorical variables were compared using non-parametric Mann-Whitney U test and Fisher exact test.Survival curves of overall survival(OS) and disease-free-survival(DFS) were plotted by Kaplan-Meier method, and compared according to Log-rank test. Results: A total of 41 patients were included. After propensity score matching, 12 patients fell into each of the two groups(totally laparoscopic approach group and open approach group). Baseline characteristics were similar between the two groups.There was no difference regarding the to the proportion of major liver resection.Statistically significant difference was observed in term of intra-operative blood loss (250 ml vs.450 ml, Z=-2.005, P=0.045) and fluid infusion(2 430 ml vs. 3 150 ml)(Z=-2.488, P=0.012). Post-operative stay and overall morbidity were similar between the two groups.However, adverse event worse than Clavien-Dindo Ⅱ morbidity did not occur in the laparoscopic approach group.No postoperative mortality happened in either group within 30 days of surgery. Regarding to long-term outcomes, OS and DFS were similar between the two approaches. Conclusion: Laparoscopic approaches for simultaneous resection of primary colorectal cancer and synchronous liver metastases may be associated with reduced blood loss, without adversely affecting long-term outcomes in selected patients.