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Changes of the growth plate in children: 3-dimensional magnetic resonance imaging analysis

Hyung Ho Yun1, Hyun-Jung Kim1, Min-Sun Jeong2

  • 1Department of Pediatrics, Eulji General Hospital, Eulji University School of Medicine, Seoul, Korea.

Korean Journal of Pediatrics
|July 24, 2018
PubMed

Insights

This pilot study observed significant increases in growth plate size and key growth markers in children over six months. Further research is needed to correlate these changes with clinical parameters in growth-retarded children.

Area of Science:

  • Pediatric Endocrinology
  • Skeletal Biology
  • Medical Imaging

Background:

  • Growth retardation in children is a significant clinical concern.
  • Understanding growth plate dynamics is crucial for assessing growth potential.
  • Insulin-like growth factor-1 (IGF-1) and IGF binding protein 3 (IGF-BP3) are key regulators of growth.

Purpose of the Study:

  • To assess changes in growth plate dimensions and growth rates in children over a 6-month period.
  • To evaluate the correlation between growth plate changes and clinical parameters in children with growth retardation.

Main Methods:

  • A pilot study involving 31 healthy children (17 boys, 14 girls) evaluated for growth retardation.
  • Measurements included height, weight, bone age, IGF-1, and IGF-BP3 at baseline and after 6 months.
  • Magnetic resonance imaging (MRI) was used to measure the diameter, thickness, and volume of femoral and tibial growth plates.

Main Results:

  • Significant increases in height, weight, BMI, IGF-1, and IGF-BP3 were observed in both boys and girls after 6 months.
  • Mean diameter and volume of the femoral and tibial growth plates significantly increased in both sexes.
  • No significant correlation was found between growth plate changes and most clinical parameters, except for femoral diameter with weight and BMI.

Conclusions:

  • Children with growth retardation showed significant increases in growth plate dimensions and key growth factors over 6 months.
  • The correlation between growth plate changes and clinical parameters requires further investigation in larger, long-term studies.
Abstract

Keywords:
ChildMagnetic resonance imagingGrowth plate

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