Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dopamine action in the nucleus accumbens.

J F DeFrance, R W Sikes, R B Chronister

    Journal of Neurophysiology
    |December 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Anabolic steroids alter the physiological activity of aggression circuits in the lateral anterior hypothalamus.

    Neuroscience·2015
    Same author

    Cross-modal plasticity after monocular enucleation of the adult rabbit.

    Experimental brain research·2002
    Same author

    Electrophysiological and behavioral output of the rat basal ganglia after intrastriatal infusion of d-amphetamine: lack of support for the basal ganglia model.

    Brain research·2001
    Same author

    The medial pain system, cingulate cortex, and parallel processing of nociceptive information.

    Progress in brain research·2000
    Same author

    Age-related changes in cognitive ERPs of attenuation.

    Brain topography·1997
    Same author

    Enhancement of attention processing by Kantroll in healthy humans: a pilot study.

    Clinical EEG (electroencephalography)·1997
    Same journal

    Deep Learning Reveals Cross-Modal Neural Representations of Auditory and Visual Mental Imagery in MEG.

    Journal of neurophysiology·2026
    Same journal

    Speech sensorimotor adaptation in young adult cochlear implant users with early implantation.

    Journal of neurophysiology·2026
    Same journal

    How Visual Context Influences Lateral Stepping Regulation While Walking on Winding Paths.

    Journal of neurophysiology·2026
    Same journal

    Simultaneous neuron evidence for much higher covariation with saccadic reaction time of superior colliculus than primary visual cortex visual responses.

    Journal of neurophysiology·2026
    Same journal

    Separate Dorsolateral Prefrontal Cortex Regions Participate in Distinct Large-Scale Networks Differentially Recruited for Social and Cognitive Control Functions.

    Journal of neurophysiology·2026
    Same journal

    Comprehensive Analysis of Auditory Nerve Fiber Responses using Fiber-Specific Modeling.

    Journal of neurophysiology·2026
    See all related articles

    Dopamine suppresses excitatory responses in the rabbit nucleus accumbens, enhancing signal clarity. This effect is frequency-dependent and suggests a contrast enhancement mechanism for hippocampal messages.

    Area of Science:

    • Neuroscience
    • Neuropharmacology

    Background:

    • The nucleus accumbens plays a crucial role in reward and motivation.
    • Dopamine is a key neurotransmitter in the brain, influencing various functions.

    Purpose of the Study:

    • To investigate the postsynaptic effects of dopamine in the nucleus accumbens.
    • To determine the influence of dopamine on neuronal responses to hippocampal input.

    Main Methods:

    • Iontophoretic application of dopamine to nucleus accumbens cells in rabbits.
    • Recording of field responses and extracellular unitary discharges.
    • Pharmacological characterization using dopamine receptor antagonists (fluphenazine, bicuculline).
    • Assessment of frequency-dependent effects of dopamine and cyclic AMP analogs.

    Related Experiment Videos

    Main Results:

    • Dopamine application suppressed excitatory field responses and unitary discharges.
    • Fluphenazine antagonized dopamine's effect, indicating receptor-specific action.
    • Dopamine's suppressive effect was observed at low (0.5 Hz) but not high (6.0 Hz) stimulation frequencies.
    • Cyclic adenosine 3',5'-cyclic monophosphate (cyclic AMP) did not replicate this frequency-specific suppression.

    Conclusions:

    • Dopamine acts postsynaptically in the nucleus accumbens to reduce neuronal excitability.
    • The frequency-dependent action of dopamine suggests a role in modulating signal transmission.
    • Dopamine may enhance the signal-to-noise ratio, improving the fidelity of hippocampal information processing.