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Lenvatinib: A Promising Molecular Targeted Agent for Multiple Cancers

Koichi Suyama1, Hirotaka Iwase1,2

  • 11 Kumamoto University Hospital Cancer Center, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan.

Cancer Control : Journal of the Moffitt Cancer Center
|July 24, 2018
PubMed

Insights

Lenvatinib, a tyrosine kinase inhibitor, shows therapeutic effects against various solid tumors like thyroid and liver cancer by inhibiting angiogenesis. Managing its adverse events, such as hypertension and proteinuria, is crucial for effective lenvatinib treatment.

Area of Science:

  • Oncology
  • Pharmacology
  • Molecular Biology

Background:

  • Lenvatinib is a multi-targeted tyrosine kinase inhibitor.
  • It targets key receptors involved in tumor angiogenesis, including VEGFR, FGFR, PDGFRα, KIT, and RET.
  • Tumor angiogenesis is critical for the growth and metastasis of various solid tumors.

Purpose of the Study:

  • To review the current status of lenvatinib.
  • To discuss the toxicity profile of lenvatinib.
  • To explore the future prospects of lenvatinib in treating specific cancers.

Main Methods:

  • Review of Phase I clinical trials conducted globally.
  • Analysis of lenvatinib's mechanism of action.
  • Compilation of data on observed therapeutic effects and adverse events.

Main Results:

  • Lenvatinib demonstrated tumor shrinkage in thyroid cancer, endometrial cancer, melanoma, renal cell carcinoma, sarcoma, and colon cancer.
  • Key adverse events include hypertension, proteinuria, diarrhea, and delayed wound healing.
  • The drug shows promise for treating thyroid cancer, hepatocellular carcinoma, renal cell carcinoma, and lung cancer.

Conclusions:

  • Lenvatinib is a promising therapeutic agent for multiple solid tumors.
  • Effective management of adverse events is essential for lenvatinib therapy.
  • Further research into lenvatinib's application in various cancers is warranted.
Keywords:
KIThypertensionlenvatinibtargeted therapythyroid cancer

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