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Iron hypothesis and coronary artery disease in geriatric patients

Hossein Mokhtari1, Babak Bagheri2, Mehdi Rasouli1

  • 1Department of Clinical Biochemistry and Immunogenetic Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Mazandaran, Iran.

Archives of Physiology and Biochemistry
|July 24, 2018
PubMed

Insights

Serum ferritin levels are associated with coronary artery disease (CAD) severity and likelihood, though not independently. Further research into iron deficiency and toxicity in CAD is warranted.

Area of Science:

  • Cardiovascular Medicine
  • Biochemistry
  • Nutritional Science

Background:

  • Iron acts as a pro-oxidant, contributing to the pathogenesis of coronary artery disease (CAD).
  • Understanding the relationship between body iron status and CAD occurrence/severity is crucial.

Purpose of the Study:

  • To investigate the association between body iron status and the occurrence and severity of CAD.
  • To evaluate novel iron indices, such as the serum free iron index, in relation to CAD.

Main Methods:

  • Coronary angiography was used to classify 225 subjects (110 males, 115 females) into CAD cases and controls.
  • Serum iron, total iron-binding capacity (UIBC), transferrin, ferritin, and a newly defined serum free iron index were measured.

Main Results:

  • Serum ferritin levels were significantly higher in CAD patients compared to controls.
  • Serum ferritin showed a significant association with CAD likelihood and severity, but this correlation diminished in the presence of classical risk factors.
  • Serum ferritin demonstrated the highest efficiency in predicting CAD among the assessed iron indices (AUC = 0.61).

Conclusions:

  • Serum ferritin, an indicator of intracellular iron, is significantly associated with CAD, but this relationship is not independent.
  • The "iron hypothesis" in CAD pathogenesis should consider both iron deficiency and iron toxicity, particularly in elderly populations where iron deficiency is common.

Keywords:
Coronaryferritinsirontransferrin

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