Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Non-modulating essential hypertension: a subset particularly responsive to converting enzyme inhibitors.

G H Williams, N K Hollenberg

    Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension
    |November 1, 1985
    PubMed
    Summary

    Identifying specific patient groups, like non-modulators, is key for effective hypertension treatment. Angiotensin converting enzyme (ACE) inhibitors specifically help non-modulators manage blood pressure with fewer side effects.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Long-term dietary sodium restriction increases adiponectin expression and ameliorates the proinflammatory adipokine profile in obesity.

    Nutrition, metabolism, and cardiovascular diseases : NMCD·2014
    Same author

    Predictors of plasma and urinary catecholamine levels in normotensive and hypertensive men and women.

    Journal of human hypertension·2013
    Same author

    Effect of mineralocorticoid receptor antagonist on insulin resistance and endothelial function in obese subjects.

    Diabetes, obesity & metabolism·2013
    Same author

    Nervousness.

    Cleveland Clinic quarterly·2010
    Same author

    Diagnosis of prostate cancer by detection of minichromosome maintenance 5 protein in urine sediments.

    British journal of cancer·2010
    Same author

    Psychoses associated with vascular disease.

    Cleveland Clinic quarterly·2010

    Area of Science:

    • Cardiology
    • Nephrology
    • Pharmacology

    Background:

    • Antihypertensive therapy aims to normalize blood pressure and minimize side effects, but poor compliance suggests the latter goal is unmet.
    • Linking specific therapies to patient subsets is crucial for advancing hypertension treatment.
    • Essential hypertension is heterogeneous, with distinct patient groups exhibiting unique responses to treatment.

    Purpose of the Study:

    • To characterize a subset of essential hypertensives known as non-modulators.
    • To explore the therapeutic implications of targeting non-modulators with specific antihypertensive agents.
    • To investigate the underlying mechanisms of non-modulator pathophysiology and treatment response.

    Main Methods:

    • Characterization of non-modulators based on their abnormal sodium handling and altered responses to angiotensin II.

    Related Experiment Videos

  • Evaluation of the effects of Angiotensin Converting Enzyme (ACE) inhibitors on blood pressure and renal vascular responsiveness in non-modulators.
  • Assessment of the potential for improved long-term side effect profiles and quality of life with targeted therapy.

    • Main Results:

    • Non-modulators exhibit a defect in sodium intake's modification of adrenal and renal vascular responses to angiotensin II.
    • ACE inhibitors partially or completely correct this defect in non-modulators.
    • ACE inhibitors restore normal renal vascular responsiveness, leading to blood pressure reduction in this subset.

    Conclusions:

    • ACE inhibitors offer a specific and effective treatment for non-modulators by addressing their underlying pathophysiology.
    • Targeted therapy for non-modulators with ACE inhibitors may lead to fewer long-term side effects compared to non-specific treatments.
    • Personalized antihypertensive strategies tailored to patient subsets like non-modulators can improve treatment outcomes and patient quality of life.