Related Experiment Video
Updated: Feb 7, 2026

Lumbar Intrathecal Injection of Gene Therapy Vectors for Central Nervous System Targeting in Mice and Rats
Published on: May 16, 2025
Effect of lumbar elevation on dilatation of the central veins in normal subjects
Young Jin Gu1, Jae Hoon Lee1, Jung In Seo2
1Department of Emergency Medicine, Dong-A University College of Medicine, 26 Daesin Gongwon-Ro, Seo-Gu, Busan, South Korea.
Background:
Increasing the size of the central veins is required to increase the success rate of central line placement and decrease complication risk. Right-sided approach for the central veins, Valsalva maneuver, and Trendelenburg position have been recommended, but these may not be available for some cases. This study aimed to determine a more convenient patient position that can result in the largest central vein diameter.
Methods:
Recruited subjects were placed in 60° and 30° upper body elevation, supine position, and 30° and 60° lower body elevation, and lumbar elevation (LE) was consecutively performed, with one position maintained for 10 min. Diameters of the subclavian vein (SCV) and internal jugular vein (IJV) were measured using high-resolution two-dimensional ultrasonography at each position.
Results:
The most suitable position on the ordinary bed for increasing central vein diameter was LE. The maximum and minimum SCV and IJV diameters in LE were significantly larger than those in the supine position (SCV: coefficients -0.633 and -0.863, p = 0.08 and 0.011, respectively; IJV: coefficients -1.09 and -1.15, p < 0.001 and = 0.001, respectively). Leg elevation for 10 min failed to dilate the central vein diameter.
Conclusion:
The LE without leg elevation produced a greater and more significant increase in central vein diameter than the supine position and may be useful for central line placement.
Related Concept Videos
Freezing Point Depression and Boiling Point Elevation
The boiling point of a liquid is the temperature at which its vapor pressure is equal to ambient atmospheric pressure. Since the vapor pressure of a solution is lowered due to the presence of nonvolatile solutes, it stands to reason that the solution’s boiling point will subsequently be increased. Vapor pressure increases with temperature, and so a solution will require a higher temperature than will pure solvent to achieve any given vapor pressure, including one...
Cardiomyopathy II: Dilated Cardiomyopathy
Measures of Central Tendency
The Central Dogma
Elevation of Intermediate Points on Vertical Curves
Normal Distribution

