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Related Experiment Video

Updated: Feb 7, 2026

Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System
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Caffeine Transiently Affects Food Intake at Breakfast.

Leah M Panek-Shirley, Carol DeNysschen, Erin O'Brien

    Journal of the Academy of Nutrition and Dietetics
    |July 24, 2018
    PubMed
    Summary
    This summary is machine-generated.

    Caffeine weakly reduced laboratory food intake but did not suppress appetite or affect free-living intake. These findings suggest caffeine is not an effective appetite suppressant for weight loss.

    Keywords:
    AppetiteBody mass indexCaffeineEnergy intakeSupplements

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    Area of Science:

    • Nutrition Science
    • Human Physiology
    • Pharmacology

    Background:

    • Caffeine is commonly included in dietary supplements marketed for weight loss.
    • Claims suggest caffeine aids in weight reduction.

    Purpose of the Study:

    • To investigate if caffeine consumption reduces food intake by suppressing appetite.
    • To determine if these effects are influenced by body mass index (BMI).

    Main Methods:

    • A double-blind, placebo-controlled, randomized crossover study involving 50 adults.
    • Participants consumed beverages with 0, 1, or 3 mg/kg caffeine before a laboratory buffet meal.
    • Food intake and appetite sensations were assessed in the lab and over 24 hours post-ingestion.

    Main Results:

    • A modest reduction (approximately 10%) in laboratory energy intake was observed at 1 mg/kg caffeine (P=0.046).
    • No significant differences in appetite sensations were found in the laboratory.
    • Neither laboratory nor free-living food intake or appetite was significantly affected by caffeine treatment or BMI interactions.

    Conclusions:

    • Caffeine exhibits weak and temporary effects on energy intake.
    • Evidence does not support caffeine as an effective appetite suppressant for weight management.