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Updated: Feb 7, 2026

Application of a Coupling Agent to Improve the Dielectric Properties of Polymer-Based Nanocomposites
Published on: September 19, 2020
Nanocomposites prepared by electrohydrodynamics and their drug release properties
Hangyi Lu1, Yuyu Qiu2, Qingqing Wang1
1Key Laboratory of Eco-textiles, Jiangnan University, Wuxi, People's Republic of China.
Abstract:
Electrohydrodynamic method was used to produce both single-drug and dual-drug loaded nanocomposites. Zein was blended with ethyl cellulose, and the mixture was electrospun into nanofibers. Polyethylene oxide was electroprayed into nanoparticles and deposited on the nanofibrous matrix. Indomethacin and tetracycline hydrochloride were loaded in the nanocomposites as model drugs. The suitable electrospraying conditions were chosen based on the result of scanning electron microscopy. Fourier transform infrared spectra indicated that components were merely physically combined. Differential scanning calorimetry and X-ray diffraction confirmed amorphous states of the drugs in the nanocomposites. The nanocomposites displayed good wettability, water-stability and improved modulus. In vitro dissolution tests revealed a desirable drug release profile, which abided by Fickian diffusion.
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