Related Experiment Video
Updated: Feb 7, 2026
Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
Published on: November 27, 2019
The perfluorinated alcohols c-C6F11OH, c-C6F10-1,1-(OH)2 and c-C6F10-1-(CF3)OH
Jonas Schaab1, Miriam Schwab, Daniel Kratzert
1Albert-Ludwigs-Universität Freiburg, Institut für Anorganische und Analytische Chemie and Freiburger Materialforschungszentrum FMF, Albertstr. 21, D-79104 Freiburg, Germany. krossing@uni-freiburg.de.
Abstract:
The thermally unstable α-fluoroalcohol undecafluorocyclohexanol (c-C6F11OH) was prepared by addition of hydrogen fluoride to the corresponding ketone. c-C6F10(CF3)OH was obtained by protonation of its alkoxide [NMe4]+[C7F13O]-. Decafluorocyclohexane-1,1-diol (c-C6F10(OH)2) was prepared by acidic workup of the corresponding alkoxide [NMe4]+[C6F11O]- with sulfuric acid, which yielded (c-C6F10(OH)2) and fluorosulfonic acid. The structures of c-C6F10(CF3)OH·2H2O and of (c-C6F10(OH)2) were elucidated by single-crystal X-ray and gas-phase electron-diffraction studies.
Related Concept Videos
02:27Predicting Products: SN1 vs. SN2
With increased substitution on the alkyl halide,...
01:261° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Overview
The nitrous acid is unstable. Hence, it is formed in situ from a solution of sodium nitrite and cold aqueous acids such as hydrochloric or sulfuric acid. In an acidic solution, the –OH group of nitrous acid undergoes protonation to give oxonium ion, followed by...
01:371° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Mechanism
02:37Oxidation of Alcohols
The process of oxidation in a chemical reaction is observed in any of the three forms:
02:29Ethers from Alcohols: Alcohol Dehydration and Williamson Ether Synthesis
Ethers can be prepared from organic compounds by various methods. Some of them are discussed below,
Preparation of Ethers by Alcohol Dehydration
In this method, in the presence of protic acids, alcohol dehydrates to produce alkenes and ethers under different conditions. For example, in the presence of sulphuric acid, dehydration of ethanol at 413 K yields ethoxyethane, whereas it yields ethene at 443 K.
02:31Protection of Alcohols
Protection
It defines a protecting group as the masking agent to make the more reactive species inert to a given set of conditions. This concept is depicted via the illustration of liquid flow through different outlets in an assembly of pipes. The analogy helps to understand the role...